Mono GalNAc TEG Phosphoramidite

Name: Mono GalNAc TEG Phosphoramidite
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R10-0047
Category	Phosphoramidites
Molecular Formula	C62H90N3O19P
Molecular Weight	1213.37

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Product Introduction

Mono GalNAc TEG Phosphoramidite is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a monovalent N-acetylgalactosamine (GalNAc) moiety attached to a phosphoramidite via a triethylene glycol (TEG) linker. The TEG linker provides flexibility and hydrophilicity, while the GalNAc ligand enables high-affinity binding to the asialoglycoprotein receptor (ASGPR) on hepatocytes, facilitating targeted delivery of oligonucleotides to the liver.

Chemical Information

Chemical Information

Synonyms	(2R,3S,4R,5R,6R)-5-Acetamido-2-(acetoxymethyl)-6-((4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-20-oxo-1-phenyl-2,6,9,12,15-pentaoxa-19-azatetracosan-24-yl)oxy)tetrahydro-2H-pyran-3,4-diyl diacetate; Mono GalNAc TEG (DMT) Phosphoramidite
SMILES	O=C(N[C@H]([C@H]([C@@H]1OC(C)=O)OC(C)=O)[C@@H](O[C@@H]1COC(C)=O)OCCCCC(NCCCOCCOCCOCCOCC(COC(C2=CC=C(C=C2)OC)(C3=CC=CC=C3)C4=CC=C(C=C4)OC)OP(N(C(C)C)C(C)C)OCCC#N)=O)C
InChI	InChI=1S/C61H89N4O19P/c1-43(2)65(44(3)4)85(80-33-16-29-62)84-54(41-79-61(49-18-12-11-13-19-49,50-21-25-52(71-9)26-22-50)51-23-27-53(72-10)28-24-51)40-76-39-38-75-37-36-74-35-34-73-31-17-30-63-56(70)20-14-15-32-77-60-57(64-45(5)66)59(82-48(8)69)58(81-47(7)68)55(83-60)42-78-46(6)67/h11-13,18-19,21-28,43-44,54-55,57-60H,14-17,20,30-42H2,1-10H3,(H,63,70)(H,64,66)/t54?,55-,57-,58-,59-,60-,85?/m1/s1
InChIKey	ZBBIFTGXXMNXRH-OMZCFCQGSA-N