Coumarin
BOC Sciences is committed to providing customers with high-quality coumarin dyes. We can modify NHS ester, azido, maleimide, amino, alkynyl, carboxyl, hydrazide and other active groups on the parent structure of coumarin.
Coumarin dyes can be used to label conjugates as well as antibodies, proteins, peptides, oligonucleotides and other biomolecules, and have a wide range of applications in bioimaging and biomarking. In addition, coumarin dyes are also suitable for preparing fluorescent substrates for detecting enzyme activity in cells and solutions.
Background
Fluorescent dye is a very important functional dye, which is widely used in industry, agriculture, medicine, textile, energy, national defense and genetic biology.
Coumarin dyes are a very important class of fluorescent dyes and can be used as fluorescent whitening agents, fluorescent pigments, and laser dyes in various fields. Coumarin is a natural product with α-benzopyrone nucleus, and is a secondary metabolite widely found in higher plants, animals and microorganisms. Coumarin itself has no fluorescence. However, the introduction of certain substituents at different positions in the coumarin structure will cause the coumarin derivatives to produce changes from yellow, red to blue-green and different fluorescence properties.
Application of coumarin dyes
Due to the double bond and lactone structure in the coumarin dye, it has strong fluorescence performance in the visible light range, has a large Stokes shift, good light stability and high photoluminescence quantum efficiency. It is extensively used in the synthesis of fluorescent probes and optical materials. In addition, coumarin dyes also have various biological activities such as antibacterial, anti-cancer, anti-tumor, anti-inflammatory, and anti-oxidation. They have strong ability to penetrate cells and can be used in biological fields such as cytology and in the production of the pharmaceutical industry. Coumarin dyes have very low cytotoxicity and can be used for in vivo imaging and cell imaging.
