7-Methoxycoumarin-4-acetic acid

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7-Methoxycoumarin-4-acetic acid

7-Methoxycoumarin-4-acetic acid | 62935-72-2

Catalog Number F06-0004
Category Coumarin
Molecular Formula C12H10O5
Molecular Weight 234.20
Catalog Number Size Price Quantity
F06-0004 -- $--
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Product Introduction

Key intermidiate for the synthesis of fluorescence probes in chromatographic detection. Shows local anesthetic activity.

Chemical Information
Synonyms 7-Methoxy-2-oxo-2H-1-benzopyran-4-acetic acid; Mca-OH; 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid; 2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetic acid; 2H-1-Benzopyran-4-acetic acid, 7-methoxy-2-oxo-; Mca-OH
Purity ≥ 98% (HPLC)
IUPAC Name 2-(7-methoxy-2-oxochromen-4-yl)acetic acid
Canonical SMILES COC1=CC2=C(C=C1)C(=CC(=O)O2)CC(=O)O
InChI InChI=1S/C12H10O5/c1-16-8-2-3-9-7(4-11(13)14)5-12(15)17-10(9)6-8/h2-3,5-6H,4H2,1H3,(H,13,14)
InChI Key ZEKAXIFHLIITGV-UHFFFAOYSA-N
Solubility Slightly soluble in Acetone, DMSO, Methanol
Density 1.367±0.06 g/cm3 (Predicted)
Appearance Off-white to light yellow powder
Boiling Point 472.9±45.0 °C (Predicted)
Melting Point 185-195 °C
  • Product Specification
Excitation 323
Emission 382
Storage Store at 2-8 °C
Signal Warning
GHS Hazard Statements H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 5
Rotatable Bond Count 3
Exact Mass 234.05282342 g/mol
Monoisotopic Mass 234.05282342 g/mol
Topological Polar Surface Area 72.8Ų
Heavy Atom Count 17
Formal Charge 0
Complexity 360
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Literatures

PMIDPublication DateTitleJournal
21695046 2011-01-01 Substrate specifity profiling of the Aspergillus fumigatus proteolytic secretome reveals consensus motifs with predominance of Ile/Leu and Phe/Tyr PloS one
21931748 2011-01-01 Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis PloS one
19674479 2009-08-13 Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival Molecular brain
18260641 2008-03-04 Small changes in the primary structure of transportan 10 alter the thermodynamics and kinetics of its interaction with phospholipid vesicles Biochemistry
15642138 2005-01-01 Local expression of matrix metalloproteinases, cathepsins, and their inhibitors during the development of murine antigen-induced arthritis Arthritis research & therapy

Patents

Publication NumberTitlePriority Date
CN-113999290-A A kind of high stability leuprolide acetate and application thereof 2021-12-29
CN-113999290-B A kind of stable leuprolide acetate and application thereof 2021-12-29
CN-113699212-A Method and screening model for screening new coronavirus main protease small-molecule inhibitor 2021-07-01
US-2022315614-A1 Reducing agents and uses thereof 2021-03-19
US-2022308043-A1 Fluorescent probes for identification and quantification of hepatic transporters in vitro and in vivo 2021-03-16

Applications of Fluorescent Probes & Dyes

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