Molecular Imaging
BOC Sciences combines deep technical knowledge with extensive development experience to produce innovative fluorescent dyes and probes designed to deliver high-performance solutions for molecular imaging. Our specialized research and development, along with precise molecular design, allows us to supply different fluorescent dyes and probes that meet the exact requirements of specific imaging platforms and experimental setups. The superior optical properties and high biocompatibility of our fluorescent reagents along with their exceptional stability result in their widespread application in advanced research fields including cell labeling, protein localization, gene expression analysis and tumor imaging.
What is Molecular Imaging?
Molecular imaging allows scientists to study biological processes by observing molecular activities in living organisms as well as in controlled laboratory settings. Molecular imaging differs from traditional anatomical imaging methods such as X-rays or CT scans because it tracks molecular and cellular processes, enabling scientists to examine body functions and structures at a molecular level in real-time dynamic settings. Molecular imaging techniques visualize target molecules by using specific probes or labeled molecules, which include fluorescent labels and radioactive isotopes. Probes used in molecular imaging consist of natural molecules or synthetic molecules with fluorescent dyes, proving extensively utilized in in vivo imaging, cell imaging, tumor detection, and drug screening because they offer high sensitivity without causing damage and can be reversed.
Technical Advantages of Our Fluorescent Reagents
Customized Service
BOC Sciences offers customized services for fluorescent reagents, allowing clients to tailor specific fluorescent dyes or probes based on experimental needs. For example, clients can select specific excitation/emission wavelengths, modifying groups, or targeting ligands to achieve personalized molecular imaging studies.High Quality and Stability
BOC Sciences adopts a strict quality control system to ensure that each batch of fluorescent reagents has high purity, high fluorescence quantum yield, and good photostability. Our products undergo multiple performance tests to maintain stable fluorescence signals in complex biological environments.Diverse Spectral Coverage
BOC Sciences' fluorescent reagents cover a wide spectral range from ultraviolet to near-infrared, meeting different imaging requirements. For instance, near-infrared fluorescent dyes (such as Cy7 and ICG) are suitable for in vivo animal imaging, while visible light dyes (such as FITC and TRITC) are ideal for in vitro cell and tissue imaging.Innovative Technology Platform
BOC Sciences possesses advanced chemical synthesis and nanomaterial preparation technology platforms, enabling the development of new fluorescent reagents. For example, its developed near-infrared II (NIR-II) fluorescent dyes have higher tissue penetration depth and resolution, providing new tools for in vivo imaging.
Explore Our Extensive Fluorescent Reagents Product Line
BOC Sciences offers a rich variety of fluorescent reagents, covering a range of products from small molecule dyes to nanomaterials, to meet diverse molecular imaging needs. Below are our main product lines:
Small Molecule Fluorescent Dyes
Fluorescent Probes
Fluorescent Labeling Reagents
- NHS Ester Fluorescent Dyes
- Maleimide-based Fluorescent Dyes
- Azide and Alkyne-based Fluorescent Dyes
Fluorescent Nanomaterials
- Quantum Dots
- Upconversion Nanoparticles (UCNPs)
- Fluorescent Silica Nanoparticles
One-Stop Customized Service to Precisely Meet Your Research Needs
In molecular imaging applications, the specificity and sensitivity of fluorescent reagents are crucial, requiring the reagents to have a high selectivity and affinity for the target molecules or structures. To meet this demand, BOC Sciences has invested substantial resources in the development of fluorescent reagents. Through advanced synthetic techniques and in-depth molecular design, we offer high-performance customized fluorescent reagents. Customers can tailor specific fluorescent probes based on experimental requirements, such as target selection, labeling location, and fluorescence performance.
Target Molecule Identification and Screening
Based on customer needs, BOC Sciences' R&D team first helps identify target molecules, such as specific proteins, DNA/RNA sequences, or organelles. Through high-throughput screening and molecular docking technologies, dyes with strong binding affinity to the target molecules and ideal fluorescence properties are selected.
Fluorescent Dye Optimization
To improve signal strength, reduce background noise, and ensure long-lasting stable fluorescence emission, BOC Sciences optimizes the structure of fluorescent dyes. These optimizations include adjusting molecular structures to enhance photostability, heat resistance, light exposure tolerance, etc., while ensuring the spectral properties of the dyes are compatible with different imaging platforms and microscope systems.
Customized Chemical Modifications
In practical applications, many labels need to covalently bond with other molecules, such as antibodies, peptides, or nanoparticles, to improve targeting and specificity. BOC Sciences offers a wide range of chemical modification methods, including chemical conjugation, PEGylation, and biotin-avidin systems, allowing for customized bonding between fluorescent reagents and other molecules without interfering with the dye's inherent properties.
Multiplex Labeling Scheme Design
For complex molecular imaging experiments, BOC Sciences can provide multiplex labeling solutions based on customer needs. By selecting fluorescent dyes with different wavelengths, researchers can simultaneously observe the behavior of multiple target molecules in a single experiment. This has significant research implications for multiplex biomarker detection, cell dynamics tracking, and disease monitoring.
Performance Verification and Optimization
Before delivering customized fluorescent reagents, BOC Sciences conducts rigorous performance verification, including testing spectral properties, fluorescence quantum yield, interference resistance, and other aspects to ensure that the customized reagents perform optimally in experimental environments.
Advanced Fluorescent Labeling Technology for Efficient and Specific Imaging
Fluorescent labeling and conjugation technologies are critical in molecular imaging experiments, enabling efficient and specific binding of fluorescent molecules to target molecules or cellular structures for precise imaging. BOC Sciences has advanced technological expertise in this field and provides various flexible and precise labeling and conjugation solutions to ensure the effectiveness and stability of fluorescent labeling, meeting various complex experimental requirements. In the fluorescent labeling process, BOC Sciences uses various chemical crosslinkers, such as isothiocyanates, amino acids, and epoxide crosslinkers, offering more diverse labeling methods. Through these chemical conjugation methods, fluorescent dyes can efficiently and stably bind to target molecules or structures, improving the accuracy of imaging.
- Fluorescent Labeling of Antibodies
- Biotin-Avidin System
- Fluorescent Labeling of Peptides
- Fluorescent Labeling of Liposomes
- Fluorescent Labeling of Proteins
- Fluorescent Labeling of RNA
- Fluorescent Labeling of DNA
- Fluorescent Labeling of Nanoparticles
- Quantum Dot Labeling Technology
- Fluorescent Labeling Carbohydrate
Innovative Design for Fluorescence Imaging Experimental Schemes
In addition to providing fluorescent reagents, BOC Sciences also offers experimental design and technical support services. Our expert team can assist customers in designing suitable fluorescence imaging experimental schemes based on research goals and experimental requirements, offering comprehensive support from sample preparation and reagent selection to imaging condition optimization. Particularly in multicolor fluorescence imaging experiments, BOC Sciences can help customers select the best fluorescent markers and pairings to avoid interference between fluorescent dyes, improving the signal-to-noise ratio and the accuracy of the data.
High-Standard Quality Control System Ensures Your Research Success
BOC Sciences implements a comprehensive monitoring and management system for the quality control of fluorescent probes. From raw material procurement and synthesis processes to final product testing, every step is strictly controlled according to international standards to ensure the performance and quality of every batch of fluorescent probes meet expected requirements. Key quality control steps include:
- Strict Selection of Raw Materials: BOC Sciences rigorously selects raw materials for fluorescent reagents, ensuring that all materials come from certified suppliers to guarantee quality and stability. This process includes quality verification of chemicals, dyes, coupling reagents, solvents, etc., ensuring that raw materials are free from impurities and meet production standards.
- Intermediate Quality Testing: During the synthesis of fluorescent probes, BOC Sciences conducts quality checks on each intermediate, including structural analysis, purity testing, and reaction process monitoring. Advanced technologies such as high-performance liquid chromatography (HPLC), mass spectrometry (MS), and nuclear magnetic resonance (NMR) are used to ensure the purity of intermediates meets design specifications and to prevent impurities from affecting the final product quality.
- Finished Product Quality Evaluation: After synthesizing the fluorescent probes, BOC Sciences conducts comprehensive quality evaluations to ensure they possess excellent optical properties, chemical stability, and biocompatibility. Evaluation indicators include fluorescence performance, purity analysis, spectral properties, stability, and batch consistency tests.
- Biocompatibility and Non-Specific Binding Testing: To ensure the safety of fluorescent probes in in vivo and in vitro experiments, BOC Sciences also performs biocompatibility tests, including cytotoxicity tests and non-specific binding tests, to ensure that the fluorescent reagents do not negatively impact experiments.
Advanced Analytical Platform
- UV-Vis Spectrophotometer
- FTIR
- NMR
- Fluorescence Spectroscopy
- HPLC
- GC
- GPC
- TLC
- LC-MS
- GC-MS
- AAS
- ICP-MS
- XRF
- DSC
- TGA
- Melting Point Apparatus
- Polarimeter
- Viscometer
- XRD
- Karl Fischer Titration
What Molecular Imaging Solutions Can We Provide for Your Study?
Cell Imaging
Fluorescent dyes and probes can be used to label specific structures or molecules within cells, such as the cell membrane, nucleus, mitochondria, and lysosomes. For example, using BOC Sciences' MitoTracker probes, dynamic changes in mitochondria can be observed in real-time.
Immunofluorescence Staining
Fluorescently labeled antibodies are key reagents in immunofluorescence staining. BOC Sciences offers a variety of fluorescently labeled antibodies to detect specific antigens in tissue sections or cells, providing important information for disease diagnosis and biological research.
In Vivo Animal Imaging
Near-infrared fluorescent dyes and nanomaterials are suitable for in vivo animal imaging, enabling real-time monitoring of tumor growth, drug distribution, and metabolic processes. For example, using BOC Sciences' Cy7 dye, the efficiency of tumor-targeted drug delivery can be tracked.
Molecular Probe Development
BOC Sciences' fluorescent probes can be used to develop novel molecular diagnostic tools. For example, fluorescence resonance energy transfer (FRET)-based probes can be used to detect protein interactions or enzyme activity.
Drug Screening and Development
Fluorescent reagents play an important role in drug screening and development. For instance, using BOC Sciences' calcium ion probes, high-throughput screening can be performed to assess the impact of drugs on intracellular calcium signaling.
FAQs About Molecular Imaging
How does molecular imaging work?
Molecular imaging is a method of detecting and imaging molecular and cellular activities within the body. It utilizes specific probes (such as radioactive markers, fluorescent molecules, or MRI contrast agents) that bind to target molecules or cells, reflecting their biological functions. Through highly sensitive devices (such as PET, CT, MRI, optical imaging, etc.), molecular-level biological processes can be observed in real-time, providing important information for early disease diagnosis, treatment response, and drug development.
What is molecular imaging used for?
Molecular imaging is widely used in medical research, clinical diagnostics, and drug development. It can be used for early diagnosis of diseases, especially cancer, cardiovascular diseases, and neurodegenerative diseases. Molecular imaging also helps assess therapeutic effects, monitor disease progression, analyze drug bio-distribution, and its metabolism in the body, supporting the development of personalized treatment plans.
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