In Vivo Imaging
BOC Sciences possesses deep expertise in creating and altering fluorescent dyes meant for in vivo imaging applications. Researchers and developers in biomedicine and clinical diagnostics widely utilize our products during drug development and diagnostic processes. We deliver high-performance fluorescent dyes with the help of ongoing technological innovation and strict quality control, which enables customers to obtain clearer and more precise outcomes in live imaging studies. BOC Sciences delivers fluorescent dyes that address diverse research applications, including small animal imaging and tumor detection as well as cell tracking.
What is In Vivo Imaging?
In vivo imaging provides a non-invasive method to monitor live organisms through real-time observation and analysis. This technique employs specific imaging probes like fluorescent dyes together with devices such as optical imaging systems, MRI, and CT to observe physiological and pathological processes inside living organisms without inflicting harm. Biomedical research benefits immensely from the capabilities of in vivo imaging. For example, in the field of oncology, researchers use fluorescently labeled probes to monitor both tumor growth and metastasis. During drug development processes, in vivo imaging allows researchers to analyze how drugs move through and are processed inside the body. Neuroscience research utilizes it to monitor both neuronal connections and activity. Highly sensitive and high-resolution imaging probes form the foundation of in vivo imaging technology, with fluorescent dyes being the most widely utilized type. Through the combination of fluorescent dyes with target molecules, researchers can detect fluorescent signals that reveal specific regions or molecular activities inside the organism.
Why Choose Our Fluorescent Dye Support Service?
Professional R&D Team
BOC Sciences has a skilled R&D team with expertise in chemistry, biology, and materials science. With extensive experience in fluorescent dye development, the team actively participates in international collaborations, ensuring cutting-edge solutions for customers.Extensive Industry Experience
With years of experience, BOC Sciences has developed high-quality fluorescent dyes widely used in in vivo imaging. Continuous process optimization enhances product quality and meets diverse customer needs.Advanced Technology Platform
Equipped with state-of-the-art R&D equipment, including fluorescence spectrometers and nano-material synthesis devices, BOC Sciences collaborates with research institutions to strengthen its R&D capabilities.Strict Quality Control
A rigorous quality control system ensures high product quality at every stage, certified under ISO9001 for consistency and reliability.
Enhance Your Assays with Our High-Quality Fluorescent Dyes
BOC Sciences has strong technical expertise and extensive experience in the synthesis and customization of fluorescent dyes. We offer a wide range of fluorescent dye products suitable for different needs in in vivo imaging. Our fluorescent dye synthesis mainly includes the following types:
Near-Infrared Fluorescent Dyes
Visible Light Fluorescent Dyes
Multifunctional Fluorescent Dyes
- Quantum Dots
- Fluorescent Probes
- Fluorescent Labeled Nanoparticles
- Antibody-Conjugated Fluorescent Dyes
Customized Modification Services for Fluorescent Dyes
BOC Sciences offers professional fluorescent dye modification services to enhance the performance of dyes in in vivo imaging. Through chemical modifications, we improve the optical properties, stability, biocompatibility, and targeting capabilities of dyes, ensuring optimal performance in specific applications. Our modification services include but are not limited to the following:
Chemical Modification
We provide a variety of chemical modifications for fluorescent dyes, such as introducing reactive groups (e.g., NHS esters, maleimides, alkynes) for covalent conjugation with biomolecules like proteins, peptides, and nucleic acids. Additionally, we can modify the dyes for hydrophilicity or hydrophobicity to improve their solubility and biocompatibility.
Targeted Modification
To enhance the accumulation of fluorescent dyes in specific tissues or cells, we can conjugate the dyes with targeting molecules (e.g., antibodies, peptides, small molecule ligands), forming targeted fluorescent probes. This type of modification is particularly suitable for applications like tumor imaging and inflammation detection.
Multifunctional Modification
We can also combine fluorescent dyes with other functional molecules (e.g., MRI contrast agents, radioactive isotopes) to create multifunctional imaging probes for multimodal imaging studies.
Bioconjugation
Using biochemical methods, we conjugate fluorescent dyes with biomolecules, such as binding fluorescent dyes with specific antibodies through antibody conjugation techniques, which are useful for detecting specific antigens in vivo. BOC Sciences has extensive experience in bioconjugation, offering efficient and specific conjugation services to ensure accurate localization and detection of fluorescent dyes in biological systems.
Nanomaterial Modification
By combining fluorescent dyes with nanomaterials like quantum dots and liposomes, we enhance dye stability and biocompatibility. BOC Sciences customizes the selection of nanomaterials according to different application needs, creating fluorescent nanomaterials with excellent optical properties and biocompatibility for in vivo imaging.
Innovative Solutions Leading New Technologies in Precision Diagnosis
BOC Sciences is actively driving the development of fluorescent dyes and biosensing technologies through continuous innovation in smart responsive probes, multimodal imaging, and adaptation to miniaturized devices. We provide high-performance solutions for medical imaging, in vitro diagnostics, and bioanalysis, accelerating the commercialization of related products.
Smart Responsive Probes
BOC Sciences is dedicated to developing high-sensitivity smart responsive fluorescent probes, especially pH-activated and enzyme-activated dyes, to significantly reduce background noise and enhance detection specificity. For example, designing dyes that are specifically activated in the tumor microenvironment by leveraging the acidic or enzyme-overexpressed characteristics of tumors ensures probe silence in healthy tissues while activation occurs only at tumor sites. This strategy not only improves imaging accuracy but also reduces the risk of misdiagnosis, advancing precision medicine.
Multimodal Imaging Integration
BOC Sciences is actively exploring fluorescence-photoacoustic dual probes to achieve synchronized structural and functional imaging. Fluorescence imaging provides high sensitivity and molecular specificity, while photoacoustic imaging offers deeper tissue penetration and high spatial resolution. Integrating these modalities compensates for the limitations of single imaging methods, delivering more comprehensive and accurate biological information. For instance, combining fluorescent dyes with photoacoustic signal conversion materials enables dynamic monitoring at the cellular and molecular levels and high-resolution tissue structure imaging through photoacoustic effects, offering powerful tools for tumor detection, brain neuroimaging, and other complex biological studies.
Adaptation to Miniaturized Devices
To promote the commercialization of portable POCT (Point-of-Care Testing) diagnostic devices, BOC Sciences is optimizing the compatibility of fluorescent dyes with photonic biosensors, focusing on miniaturization and integration. By adjusting the spectral properties, quantum yield, and stability of dyes, we achieve better matching with the excitation and detection wavelengths of miniaturized sensors, enhancing detection sensitivity and signal stability. Breakthroughs in this field will provide more convenient and efficient solutions for early disease screening, rapid infectious disease testing, and personalized medicine.
Bioconjugation Strategies
To further enhance the stability and biocompatibility of fluorescent probes, BOC Sciences is optimizing bioconjugation strategies. We employ highly efficient approaches such as click chemistry, bioorthogonal labeling, and PEGylation to improve the conjugation efficiency between fluorescent dyes and biological targets, including antibodies, proteins, and oligonucleotides. These optimized techniques are applicable to high-sensitivity immunoassays, single-molecule fluorescence tracking, and high-throughput screening, providing strong technological support for precision diagnostics.
Comprehensive Quality Testing Services Ensuring Fluorescent Dye Reliability
BOC Sciences possesses advanced testing equipment and a professional technical team to provide high-precision and high-sensitivity quality testing services. Our researchers strictly follow international standards and industry regulations to ensure the accuracy and reliability of test results. With a rigorous quality control system, BOC Sciences guarantees that every batch of fluorescent dyes meets high-quality standards, offering reliable tools for in vivo imaging.
- Purity Analysis: BOC Sciences utilizes advanced analytical techniques to ensure high-purity fluorescent dyes with minimal impurities, guaranteeing reliable experimental results.
- Fluorescence Intensity Testing: We conduct precise fluorescence intensity measurements to evaluate dye brightness and stability, ensuring consistent optical performance in various applications.
- Photostability Testing: Our rigorous testing assesses the resistance of fluorescent dyes to photobleaching, maintaining fluorescence signals for long-term imaging and analysis.
- Biocompatibility Testing: BOC Sciences evaluates the biocompatibility of fluorescent dyes to confirm their safety and suitability for in vivo imaging and biological applications.
- Targeting Performance Testing: We verify the specificity and targeting efficiency of fluorescent dyes to ensure accurate binding and enhanced imaging precision.
- Batch Consistency Testing: Our strict quality control system ensures batch-to-batch consistency in fluorescence properties, stability, and performance for reliable results.
Advanced Analytical Platform
- UV-Vis Spectrophotometer
- FTIR
- NMR
- Fluorescence Spectroscopy
- HPLC
- GC
- GPC
- TLC
- LC-MS
- GC-MS
- AAS
- ICP-MS
- XRF
- DSC
- TGA
- Melting Point Apparatus
- Polarimeter
- Viscometer
- XRD
- Karl Fischer Titration
Which Types of In Vivo Imaging Are You Interested in Studying?
Tumor Imaging
Our near-infrared fluorescent dyes (such as Cy7 and ICG) can specifically label tumor cells by binding to specific receptors on the surface of tumor cells, providing real-time monitoring of tumor growth, metastasis, and therapeutic effects. These dyes are excited under near-infrared light to produce strong fluorescent signals, helping researchers accurately locate tumors and dynamically observe them. In addition, fluorescence imaging offers high resolution and low invasiveness, significantly improving the accuracy of early tumor detection and treatment efficacy evaluation.
Vascular Imaging
By labeling vascular endothelial cells with fluorescent dyes, researchers can clearly observe biological processes such as angiogenesis, hemodynamic changes, and vascular permeability. These fluorescent dyes selectively bind to vascular endothelial cells, marking vascular structures and providing essential tools for cardiovascular disease research. Using vascular imaging techniques, scientists can gain in-depth insights into the mechanisms of angiogenesis and investigate its roles in tumor growth, wound healing, and other pathological conditions, thus offering a theoretical basis for clinical treatments.
Cell Tracking
Our fluorescent dyes effectively label stem cells, immune cells, and more, enabling researchers to track their migration, distribution, and function in vivo. Fluorescently labeled cells can be dynamically observed in living organisms using imaging systems, allowing researchers to precisely monitor cell behavior, localization, and changes in different environments. This technology has broad applications in stem cell therapy, immunotherapy, and cell engineering, providing crucial data support for basic research and clinical treatments.
Drug Delivery Research
By combining fluorescent dyes with drug carriers, researchers can observe the distribution, release, and metabolism of drugs in real time within the body. These fluorescently labeled drug carriers help scientists evaluate drug targeting, delivery efficiency, and accumulation at target sites, thus optimizing drug design and therapeutic strategies. Additionally, drug delivery research reveals interactions between drugs and other biological components, contributing to the enhanced efficiency and safety of new drug development.
Inflammation Detection
Our targeted fluorescent probes specifically label inflammation sites, enabling researchers to monitor the occurrence and progression of inflammatory responses in real time. By labeling inflammation-related molecules or cells, fluorescent probes provide high-resolution real-time imaging within the body. This technology is useful for studying different types of inflammatory responses, such as infections, injuries, or autoimmune diseases, and helps evaluate the effectiveness of anti-inflammatory treatments. By precisely monitoring the dynamic process of inflammation, researchers can better understand its mechanisms and develop more effective therapeutic strategies.
FAQs About In Vivo Imaging
What is the meaning of in vivo imaging?
In vivo imaging refers to imaging techniques performed within living organisms to observe and analyze internal structures, functions, and physiological processes. By using various imaging methods, such as fluorescence imaging, magnetic resonance imaging (MRI), or computed tomography (CT), researchers can monitor disease progression, drug responses, and biomarker changes in real time, aiding biomedical research and clinical diagnosis.
What is the principle of in vivo imaging system?
An in vivo imaging system captures internal images of living organisms using specific imaging techniques. These systems typically rely on contrast agents, fluorescent probes, or radioactive tracers, which can bind to targets within the body. Using imaging technologies (such as fluorescence, X-ray, ultrasound, etc.), these systems generate visualized images, enabling researchers to observe dynamic processes, pathological changes, and drug responses within living organisms.
What is fluorescent dye for in vivo?
Fluorescent dyes for in vivo use are molecules that label live tissues or cells and emit light at specific wavelengths, allowing researchers to visualize and track these markers within living organisms. They are widely used in biomedical research, including tumor localization, cell tracking, and drug distribution studies. These dyes offer high sensitivity and low toxicity, making them suitable for dynamic real-time imaging.
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