Drug Delivery
BOC Sciences offers a diverse range of fluorescent dyes and probes in the field of drug delivery, with robust capabilities in custom synthesis and labeling modification. We provide fluorescent dyes with various spectral properties, including near-infrared dyes and environment-sensitive probes, tailored for specific drug carriers such as liposomes, nanoparticles, and antibodies. These dyes support real-time imaging and in vivo distribution monitoring. BOC Sciences possesses advanced analytical platforms and stringent quality control systems to ensure high dye purity, superior labeling efficiency, and strong stability, meeting the demands from R&D to industrial-scale applications. With extensive project experience and a professional technical team, we provide strong support for visual research and mechanistic studies of drug delivery systems.
Technical Superiority of Our Fluorescent Labeling Reagents
High Purity and Stability
All dye products undergo ≥95% HPLC purity testing to ensure high chemical and photostability in biological environments, preventing signal decay or non-specific binding.Multi-functional Reactive Modifications
We offer dye derivatives with functional groups such as NHS ester, maleimide, DBCO, azide, alkyne, and biotin, facilitating covalent conjugation with a variety of biomacromolecules (e.g., antibodies, proteins, PEG).Multiple Wavelength Options
A broad range of excitation/emission wavelengths from UV to near-infrared (UV-Vis-NIR) is available, compatible with multispectral detection platforms such as IVIS, flow cytometry, and confocal microscopy.Personalized Custom Services
We support special requests from clients, including dye structure modification, probe conjugation synthesis, FRET pair development, and combinatorial dye packaging, broadly supporting different stages from scientific research to industrial applications.
Fluorescent Labeling Solutions in Drug Delivery
With deep expertise in organic synthesis and an extensive dye platform, BOC Sciences provides high-performance fluorescent dyes and probe products and custom services to global research institutions, pharmaceutical companies, and CDMOs, playing a critical role in the field of drug delivery. Through rigorous quality control systems (including HPLC, MS, NMR) and cGMP laboratory conditions, BOC Sciences ensures product stability, specificity, and sensitivity in complex biological systems, suitable for end-to-end demands from basic research to industrial development.
Visualization Tracking of Drug
Delivery SystemsIn drug delivery systems (DDS) such as liposomes, polymer nanoparticles, and metal-organic frameworks (MOFs), dye labeling is commonly used for in vivo distribution tracking. BOC Sciences provides dyes such as FITC, Rhodamine B, Cy5.5, and Cy7, supporting:
- Observation of cellular uptake kinetics (confocal microscopy)
- In vivo imaging in small animals (IVIS system)
- Evaluation of blood circulation half-life
- Accumulation and localization in target tissues
Monitoring of Drug Release Behavior
BOC Sciences designs fluorescent probes responsive to specific stimuli (e.g., pH, enzymes, reductive environments). When the drug is released from the carrier, the fluorescence signal changes, enabling evaluation of:
- Drug release rate
- Precision of release location
- Release behavior of pH-responsive polymer micelles
- Signal changes after enzymatic cleavage near active sites
- Validation of reductive release mechanisms in the tumor microenvironment
Evaluation of Targeting Efficiency and Intracellular Transport
By co-modifying drug carriers with targeting ligands (e.g., antibodies, folic acid, RGD peptides) and fluorescent labels, their accumulation capacity in target cells or tissues can be verified. Our products can be used for:
- Targeting ligand verification
- Tracking phagocytosis/pinocytosis pathways
- Endosome-lysosome escape analysis
- Confocal fluorescence imaging
- In vivo fluorescence imaging in animals
One-Stop Custom Technology Platform for Drug Delivery
We understand that the application of fluorescent labeling in drug delivery systems depends heavily on targeting specificity, stability, fluorescence intensity, and system compatibility. Therefore, from product development, molecular design, to conjugation strategies and downstream applications, BOC Sciences is equipped with professional teams and advanced platforms to ensure optimal solutions for every client.
Fluorescent Dye Conjugation and Labeling Services
BOC Sciences provides customized biomacromolecule fluorescent labeling services, covering a wide range of molecular types including proteins, antibodies, peptides, oligonucleotides, PEG derivatives, liposomes, and polymers. We offer:
- Conjugation strategies using various reactive groups (NHS, Maleimide, Azide, DBCO, Click Chemistry).
- Precise control of the degree of labeling (DOL) to avoid signal oversaturation or functional loss.
- Post-labeling purification and structural validation (HPLC, SEC, MS, etc.).
This service is widely applied in quantitative evaluation of targeted drug delivery systems, cellular uptake tracking, and pharmacokinetic studies both in vitro and in vivo.
Probe Structure Optimization and Custom Synthesis Services
BOC Sciences provides professional structural optimization services for probes, designing structures with enhanced biocompatibility, targeting ability, and imaging efficiency according to the physicochemical properties of various drug delivery platforms. These include but are not limited to:
- Hydrophobicity modulation design to enhance probe encapsulation efficiency in liposomes or polymer nanoparticles.
- Optimization of linker length and flexible segments to improve fluorophore exposure and signal intensity.
- Introduction of pH/enzyme/redox-responsive groups to achieve intelligent monitoring of delivery processes.
In addition, we offer molecular customization for high-end dye systems such as FRET, BODIPY, and near-infrared excitation dyes to meet stringent performance demands from research clients.
Collaborative Development of Multimodal Probes
To meet increasingly complex research needs in drug delivery systems, single fluorescent imaging is often insufficient for multidimensional data collection. BOC Sciences offers co-development services for multimodal probes to help build integrated probe systems with multiple signal functions, including:
- Fluorescence + Radioactivity: combining PET/SPECT imaging with high-resolution fluorescence detection.
- Fluorescence + MRI: integrating spatial structure and functional distribution information.
- Fluorescence + Photothermal/Photodynamic: enabling theranostic probe design.
This service is particularly suitable for novel nano-delivery systems, tumor-targeted therapies, and companion diagnostics, facilitating multi-scale observation and evaluation from molecules to cells to animal models.
Application Guidance and Technical Support Team
BOC Sciences is equipped with a professional technical support team consisting of PhDs and engineers with multidisciplinary backgrounds in molecular imaging, drug delivery, and biomaterials. The team provides:
- Experimental protocol design support: recommending the most suitable dyes and labeling methods for various drug delivery projects.
- Conjugation optimization suggestions: adjusting linkage strategies based on targets like proteins or nanocarriers.
- Imaging analysis assistance: supporting fluorescence intensity normalization and quantitative analysis of imaging results in vitro and in vivo.
Additionally, BOC Sciences supports long-term collaboration mechanisms with domestic and international universities, research institutions, and biopharmaceutical companies, promoting the application and commercialization of high-value fluorescent tools in drug delivery systems.
Customized Service Process and Analytical Platforms
As a leading provider of fluorescent dyes and probe solutions, BOC Sciences has built an efficient, precise, and traceable service workflow based on its extensive experience in chemical synthesis and drug delivery. This ensures every step, from project initiation to final delivery, is transparent, responsive, and quality-assured.
- Requirement Communication and Project Evaluation: Upon receiving the customer's application requirements, we respond within 24 hours with initial technical consultation and assess the project's feasibility, technical route, and customization direction.
- Technical Proposal Design and Quotation: Based on the target molecule and application scenario, we develop a tailored dye labeling or probe synthesis plan, along with a detailed quotation, delivery schedule, and contract support.
- Custom Synthesis and Labeling Execution: Our experienced team conducts fluorescent dye design, functional modification, and conjugation operations to ensure rational structures and efficient reactions, all in accordance with standardized procedures.
- Purification, Testing, and Quality Control: Products undergo various tests including HPLC, mass spectrometry, and spectrophotometry to strictly control purity, labeling efficiency, and photostability, ensuring batch-to-batch reliability.
- Packaging, Delivery, and After-sales Support: Products are securely delivered using light-proof and moisture-resistant packaging, accompanied by technical documentation and experimental recommendations. We offer continued optimization, application consulting, and long-term technical collaboration.
Analytical Platforms
- High-Performance Liquid Chromatography (HPLC)
- Liquid Chromatography-Mass Spectrometry (LC-MS)
- UV-Visible Spectrophotometer
- Fluorescence Spectrophotometer
- Gel Permeation Chromatography
- Size Exclusion Chromatography (GPC/SEC)
- Gas Chromatography-Mass Spectrometry (GC-MS)
- Nuclear Magnetic Resonance (NMR)
- Dynamic Light Scattering (DLS)
- Fourier Transform Infrared Spectroscopy (FTIR)
- Confocal Laser Scanning Microscope (CLSM)
- Multimode Microplate Reader
Fluorescence-Based Solutions for Drug Delivery Applications
BOC Sciences is committed to building a one-stop fluorescence tool platform that provides accurate, stable, and user-friendly fluorescence solutions for both drug delivery research and industrial translation. We continually expand our probe library and develop new fluorescent labeling strategies to help clients meet diverse and sophisticated research needs in drug delivery.
Tracking of Nanodrug Delivery Systems
We provide high-sensitivity fluorescent dyes for covalent or non-covalent labeling of carriers such as nanoparticles, polymer micelles, and nanogels. These are suitable for in vivo and in vitro imaging, enabling studies on blood circulation time, tissue targeting capacity, cellular uptake efficiency, and intracellular trafficking pathways, thereby enhancing the design and evaluation of nanodelivery systems.
Imaging of Liposomes and Solid Lipid Nanoparticles (SLNs)
For lipid-based delivery systems such as liposomes and SLNs, we offer hydrophobic membrane-inserting dyes and polar interface probes to study membrane stability, drug release kinetics, fusion with cellular membranes, and intracellular transport processes—supporting the development of efficient and safe lipid drug carriers.
Validation of Antibody-Drug Conjugate (ADC) Delivery
We offer high-stability fluorescent labeling for the antibody, linker, or drug components in ADCs, enabling in vivo targeting validation and monitoring of cellular internalization and dissociation processes. This provides visual support for ADC structure optimization and preclinical pharmacokinetic studies.
Nucleic Acid Drug (siRNA/mRNA/DNA) Delivery Research
We provide specialized fluorescent labeling technologies for RNA and DNA, which can be used in conjunction with lipid-based or cationic polymer delivery systems. These allow monitoring of transfection efficiency, intracellular release timing, and degradation pathways—making them ideal tools for evaluating gene drug delivery performance.
Cell-Penetrating Peptides (CPPs) and Transmembrane Mechanism Studies
By fluorescently labeling transmembrane peptides, proteins, or co-delivery molecules, we enable dynamic imaging analysis of their membrane-crossing abilities, endocytic mechanisms, and subcellular localization. This supports the elucidation of CPP mechanisms in drug delivery and aids in the optimization of structural design.
FAQs
What types of fluorescent dyes and probes do you offer?
We provide a wide range of fluorescent dyes and functionalized probes, including hydrophilic/hydrophobic dyes, reactive group-labeled dyes (e.g., NHS, maleimide, azide), organelle-targeting probes, responsive probes (pH, ROS, enzymes), and near-infrared dyes. These are compatible with various delivery platforms and experimental needs.
Do you support customization of specific dye structures?
Yes, we support customer-defined structures, including the dye core, linker length, and reactive group types. Customers can provide the target structure or technical parameters, and we will customize accordingly based on synthetic feasibility, purity requirements, and application goals.
Can the fluorescent dyes be used in animal in vivo experiments?
We provide near-infrared fluorescent dyes (such as Cy7, IRDye series) suitable for in vivo imaging, featuring good tissue penetration and biocompatibility. For in vivo applications, we can also help evaluate dye photostability and toxicity risks.
Do you offer support for carrier labeling or conjugation services?
Yes. In addition to supplying pure dyes, we offer fluorescence labeling services for proteins, antibodies, nanoparticles, liposomes, nucleic acids, and more. Services include optimization of labeling ratios, removal of free dye, and stability testing.
Are labeled samples purified and quality-analyzed?
Yes, all custom-labeled samples undergo purity analysis using platforms such as HPLC, UV-Vis, and MS. Upon request, we can provide a complete analytical report to ensure product quality and experimental reproducibility.
How do I choose the right dye type for my system?
We can recommend the most suitable dye type based on your delivery system (e.g., liposomes, polymers, proteins), experimental platform (e.g., cell, animal, confocal), and target signal range. We also provide wavelength, solubility, and compatibility data.
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