ICG Dyes

ICG Azide CAT: F09-0001 INQUIRY
ICG ADIBO CAT: F09-0002 INQUIRY
ICG PEG4-Alkyne CAT: F09-0003 INQUIRY
ICG Alkyne CAT: F09-0004 INQUIRY
ICG Hydrazide CAT: F09-0005 INQUIRY
ICG Dichlorotriazine CAT: F09-0006 INQUIRY
ICG Thiol CAT: F09-0007 INQUIRY
ICG Amine CAT: F09-0008 INQUIRY
ICG Maleimide CAT: F09-0009 INQUIRY
ICG Carboxylic acid CAT: F09-0010 INQUIRY
ICG Isothiocyanate CAT: F09-0011 INQUIRY
ICG Sulfo-NHS ester CAT: F09-0012 INQUIRY
ICG Vinylsulfone CAT: F09-0013 INQUIRY
ICG NHS ester CAT: F09-0014 INQUIRY
ICG (water-soluble) CAT: F09-0015 INQUIRY
ICG CAT: F09-0016 INQUIRY

Background

BOC Sciences is committed to providing customers with high-quality ICG dyes.

Indocyanine green (ICG) is a tricarbocyanine dye with good water solubility and molecular weight of 775. ICG can almost completely bind to plasma protein in plasma and whole blood, and has almost no toxic and side effects in vivo. As a functional dye molecule, ICG has unique photophysical and photochemical characteristics.

Characteristics of ICG Dyes

ICG is a three-carbon cyanine dye with near-infrared characteristic absorption peak. Different from Cy3, Cy5 and Cy 7 cyanine dyes, ICG has higher absorption and emission wavelength. The maximum emission wavelength is between 795 ~ 845 nm, ICG binds to red blood cells better than Cy 7, and has the characteristics of amphiphilic structure, both hydrophilic and lipophilic. The penetration depth of near-infrared light in tissue is large, and it is less affected by the background of biological tissue. Because ICG has the characteristics of near-infrared absorption and fluorescence emission, it can be used as an excellent tissue penetrating agent in vivo. Indocyanine green is also a negatively charged polyacetylene dye, which can combine with protein to form a non-covalent fluorescent complex. This "pseudo fluorescent" characteristic is used for protein determination by capillary electrophoresis and semiconductor laser-induced fluorescence detection.

Application of ICG Dyes

At present, ICG is mainly used in clinical auxiliary diagnosis of liver function, cardiac output, retinal and choroidal vascular system, such as liver cirrhosis, toxic liver disease, liver fibrosis, tenacious hepatitis and other liver diseases. It can also be used to detect the reserve function of the liver and judge the degree of liver damage.
In addition, ICG can be used as choroidal angiography agent to determine the location of choroidal diseases. With the development of science and technology, researchers use ICG as a fluorescent probe to realize real-time fluorescence imaging during surgery.
The photothermal properties of ICG are found and utilized to make it absorb near-infrared light and convert it into heat energy or produce singlet oxygen, destroy tumor cells and realize photothermal treatment of tumors. However, the instability of ICG in aqueous solution, the rapid clearance rate in blood circulation and the lack of tumor cell targeting seriously limit its application in tumor diagnosis and treatment. Therefore, in recent years, researchers have designed and synthesized a variety of nano carriers to carry ICG in order to improve its stability, prolong blood circulation time and give it tumor targeting.

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