Fluorescent Nanoparticle Services
Fluorescent nanoparticles are a class of nanomaterials with sizes ranging from 1 to 100 nanometers that can emit fluorescent signals. They integrate the optical properties of traditional fluorescent dyes with the unique physicochemical characteristics of nanomaterials, and are widely used in fields such as bioimaging, sensing, drug delivery, environmental detection, and security labeling. BOC Sciences' fluorescent nanoparticle synthesis service focuses on high sensitivity, high stability, and high customization, covering the full process from molecular design, particle size control to surface functionalization, serving a wide range of cutting-edge fields including bioimaging, molecular probes, drug delivery, in vitro diagnostics, environmental monitoring, and materials engineering.
What Benefits Do Fluorescent Nanoparticles Offer?
Strong Photostability
Compared to traditional dyes, fluorescent nanoparticles are less prone to photobleaching, suitable for long-term imaging and repeated excitation.Good Water Solubility
Surface modification enhances water solubility, allowing stable dispersion of particles in biological systems, suitable for both in vivo and in vitro experiments.Controllable Particle Size and Function
Particle size can be controlled, and various functional groups can be introduced on the surface to achieve targeted recognition and functional expansion.Multiplex Labeling Capability
With narrow emission spectra and broad excitation features, they can simultaneously label multiple targets, increasing detection throughput.
Fluorescent Nanoparticle Services Supported by BOC Sciences
BOC Sciences possesses advanced fluorescent nanoparticle synthesis technologies, including sol-gel, self-assembly, hot injection, microemulsion polymerization, and other process routes. We can precisely control nanoparticle size, morphology, and fluorescent properties, supporting customized synthesis for various material systems (such as carbon, metals, polymers, silica, etc.). Meanwhile, through surface functionalization techniques, multiple bioactive groups such as carboxyl, amino, PEG, antibodies, and others can be introduced to meet diversified application needs including targeted imaging, drug delivery, and molecular probes.
Fluorescent Carbon Nanoparticles
Prepared based on carbon dots or graphene quantum dots, they possess good water solubility, low toxicity, and environmental friendliness, widely used in cell imaging, metal ion detection, and fluorescent sensor development.
Fluorescent Gold
NanoparticlesLuminescence is achieved through metal clusters, surface-conjugated dyes, or energy transfer mechanisms. Coupled with excellent biocompatibility and surface modification ability, they are commonly used in biological probes, targeted imaging, and immunoassays.
Fluorescent Silver
NanoparticlesFeaturing unique plasmon resonance and enhanced fluorescence effects, they can be used for photonic enhancement probes, antibacterial materials, and high-sensitivity analytical system construction.
Fluorescent Magnetic Nanoparticles
Combining magnetic nanoparticle cores (such as Fe₃O₄) with fluorescent shells, they provide dual functions of magnetic separation and optical imaging, suitable for targeted separation, magnetic resonance enhanced imaging, and multimodal diagnostic platforms.
Fluorescent Organic Nanoparticles
Formed by self-assembly of organic dyes or doping polymers, featuring tunable colors, strong emission, and diverse structures. They are applicable in fluorescent probes, molecular tracking, and drug release monitoring.
Fluorescent Silica
NanoparticlesPrepared by sol-gel methods, often used to embed dyes or quantum dots, with good physical stability and biocompatibility, suitable for constructing targeted labeling and multifunctional probe systems.
Fluorescent Polymer Nanoparticles
Including carriers such as polystyrene (PS), PLGA, polyvinyl alcohol (PVA), polymethyl methacrylate (PMMA), suitable for dye doping, surface modification, and biofunctionalization, widely applied in cell imaging, delivery systems, fluorescent encoding, and in vitro diagnostics.
Fluorescent Lipid
NanoparticlesMainly composed of lipids, mimicking biological membrane structures, with good biocompatibility and membrane fusion ability. Fluorescent lipid nanoparticles are commonly used in drug delivery, gene transfer, and cell imaging.
Looking for Expert Guidance?
BOC Sciences leverages advanced fluorescence technologies to propel your research forward, enabling next-generation breakthroughs in drug discovery and diagnostics.
Comprehensive Capabilities from Design to Analysis
BOC Sciences specializes in custom synthesis of high-performance fluorescent nanoparticles, serving multiple research and industrial fields including bioimaging, diagnostic reagents, sensing analysis, and drug delivery. Leveraging mature materials synthesis platforms and surface modification technologies, we provide one-stop solutions from nanoscale structure design to targeted functionalization, ensuring each batch meets customers’ specific requirements and application standards.
Customization of Fluorescent Core Materials
- Offering various types of fluorophores including organic fluorescent dyes, quantum dots (QDs), carbon dots (CDs), dye-doped nanoparticles, metal nanoclusters, etc.
- Adjustable emission wavelengths (from ultraviolet to near-infrared) and luminescence intensity, supporting multicolor labeling and multimodal imaging needs.
Particle Size Control
- Particle size range: 2 nm – 200 nm;
- Precise size design according to application scenarios (such as cell imaging, tissue penetration, blood circulation);
- Complete size characterization data provided, including TEM, DLS, etc.
Surface Functionalization
- Common functional groups: carboxyl, amino, thiol, hydroxyl;
- Support conjugation of antibodies, oligonucleotides, aptamers, peptides, PEG, etc.;
- Achieve advanced functions such as targeted recognition, molecular probes, immunolabeling.
Carrier Coating and Protection
- Encapsulation with polymer shells (silica, PLGA, liposomes, etc.) available;
- Enhance fluorescence stability, biocompatibility, and in vivo circulation time;
- Provide core-shell structure design services.
Optimization of Water Solubility and Biocompatibility
- Hydrophobic nanoparticles can be modified to hydrophilic types, supporting dispersion in aqueous phase;
- PEGylation or green synthesis options to reduce cytotoxicity available.
Quality Control and Technical Support
- Provide complete characterization data: fluorescence spectra, Zeta potential, particle size distribution, TEM/SEM images;
- Support pilot scale-up, long-term supply, and technology transfer;
- Offer COA, QC reports, and technical consultation services.
Advantages of Fluorescent Nanoparticle Services
- Multiple Material Platforms: Supports customization of various fluorescent nanoparticles including carbon, gold, silver, polymer, silica, organic, and magnetic types, adapting to different application needs.
- Precise Control of Particle Size and Fluorescence: Particle size can be tuned within the 2–200 nm range, with precise design of specific emission wavelengths and brightness; performance is stable and adjustable.
- Multicolor Fluorescence Options: Provides emission color choices across the full spectrum from ultraviolet to near-infrared, supporting multiplex labeling, optical encoding, and complex sample multichannel analysis.
- Highly Functionalized Modification Capability: Particle surfaces can be functionalized with carboxyl, amino, PEG, antibodies, nucleic acids, etc., enabling targeted recognition, molecular probes, and delivery system functionalities.
- Excellent Water Solubility and Biocompatibility: Prepared using hydrophilic modifications and biocompatible materials; particles are stably dispersed with low toxicity, suitable for both in vivo and in vitro imaging and diagnostic applications.
- Strict Quality Control System: Equipped with a full set of testing platforms including DLS, TEM, Zeta potential, and fluorescence spectroscopy to ensure high consistency and reliable data for every batch.
- Flexible Customization and Rapid Response: Supports customized services from milligram-scale samples to pilot-scale production, with efficient response to meet different stages of research, development, and industrial translation.
Customized Service Content and Process
We offer end-to-end solutions for fluorescent nanoparticles, covering needs assessment, custom design, production, and quality control. Our streamlined workflow ensures efficient collaboration and delivers high-quality, precise products to support your research and industrial applications. With a team of experts optimizing every step, we help accelerate your projects and drive innovation forward.
Needs Survey and Technical Evaluation
Before project initiation, we communicate in depth with customers to clarify target applications, nanoparticle material types, fluorescence emission wavelengths, particle size ranges, and surface modification requirements. A preliminary feasibility assessment is conducted to lay the foundation for subsequent plan formulation.
Technical Route Design
Based on customer parameters and application goals, we formulate specific particle synthesis routes including fluorophore selection, particle structure design (solid or core-shell), surface coating materials, and functional modification strategies, ensuring the process is scientifically reasonable.
Sample Preparation and Characterization
Target particles are prepared using suitable methods such as sol-gel, hot injection, microemulsion, etc. Comprehensive product quality is evaluated by measuring particle size distribution via DLS, morphology observation by TEM, luminescence performance through fluorescence spectroscopy, and dispersion stability by Zeta potential analysis.
Customized Functional Modification
According to application needs, bioactive groups such as antibodies, peptides, aptamers, PEG, or small molecule ligands can be introduced on particle surfaces to achieve targeted recognition, cellular uptake, immunolabeling, and enhance biological adaptability and specificity.
Quality Control and Reporting
Each batch undergoes rigorous testing to ensure consistency in particle size, fluorescence performance, dispersion, and surface functional stability. Detailed quality control reports (including spectra, data, and methods) are provided for customer traceability and project documentation.
Scale-up and Delivery
Upon successful sample verification, we provide batch preparation services from milligrams to grams, supporting experimental research, pilot development, or long-term supply needs. Delivery formats include solutions, lyophilized powders, or other specified packaging.
Applications Supported by Fluorescent Nanoparticles
The fluorescent nanoparticles provided by BOC Sciences, with excellent optical performance and high customization, are widely applied in cutting-edge fields such as life sciences, diagnostic medicine, environmental monitoring, and materials engineering. Leveraging flexible synthesis processes and diverse functional modifications, we help customers achieve efficient innovation from basic research to clinical translation, meeting diverse scientific and industrial demands.
Cell and Tissue Imaging
Due to their high brightness, stability, and controllable size, fluorescent nanoparticles are ideal tools for cell and tissue imaging. They can penetrate cell membranes to achieve high-resolution localization of intracellular substructures and live tissues, supporting dynamic tracking and pathological diagnosis, greatly enhancing visualization in life science research.
Molecular Probes and Immunolabeling
By surface conjugation of antibodies, nucleic acid aptamers, or peptides, fluorescent nanoparticles can specifically recognize target molecules and serve as highly sensitive molecular probes in immunofluorescence labeling, protein detection, and disease biomarker analysis. Their multicolor emission supports multiplex labeling, enhancing detection flexibility and accuracy.
Targeted Drug Delivery Tracking
Fluorescent nanoparticles can serve as drug carriers and simultaneously monitor drug distribution and release dynamics in vivo via fluorescence signals. Targeted modification enables precise recognition of lesion areas, improving drug delivery efficiency, reducing side effects, and providing effective means for precision medicine and treatment evaluation.
IVD In Vitro Diagnostic Development
In in vitro diagnostics, fluorescent nanoparticles as labeling agents significantly enhance the sensitivity and specificity of immunoassays and nucleic acid detection. Their stable fluorescence properties and tunable emission wavelengths assist in developing multichannel, high-throughput diagnostic kits to meet the stringent demands of modern medical testing.
Environmental Monitoring and Fluorescent Sensing
Fluorescent nanoparticles, with their sensitive response to specific chemicals, are widely used for detecting and monitoring environmental pollutants. They efficiently detect heavy metal ions, organic pollutants, and other environmental indicators, enabling rapid, sensitive, and onsite environmental safety assessment.
Multiplex Labeling and Optical Encoding Systems
Using fluorescent nanoparticles with different emission wavelengths enables simultaneous multi-target detection and sample optical encoding within the same system. This technology is widely applied in high-throughput drug screening, cell sorting, and multiparameter analysis of complex biological samples, significantly improving detection efficiency and data dimensionality.
FAQs About Fluorescent Nanoparticles
What are fluorescent nanoparticles?
Fluorescent nanoparticles are typically nanosized particles (1–100 nm) that emit fluorescence when excited by specific wavelengths of light. They can be made from materials such as quantum dots, carbon dots, silica, metals, or polymers, possessing strong and stable fluorescence properties, widely used in imaging and sensing fields.
What are fluorescent nanoparticles used for?
Fluorescent nanoparticles are widely applied in biomedical imaging, diagnostic detection, environmental sensing, drug delivery, and materials science. Their bright and stable fluorescence enables high-resolution imaging, sensitive biomolecule detection, targeted drug tracking, and multiplex assays, facilitating research and clinical applications.
What are fluorescent nanoparticles used for in humans?
In human medicine, fluorescent nanoparticles are mainly used for high-sensitivity medical imaging to observe cells and tissues; for targeted drug delivery with real-time therapeutic tracking; and for diagnostic detection enabling early disease identification. They play important roles in cancer imaging, treatment monitoring, biomarker detection, and personalized medicine.
What is the size range of fluorescent nanoparticles?
BOC Sciences can precisely control fluorescent nanoparticle sizes, generally ranging from 2 nm to 200 nm, to meet various application requirements.
Can fluorescence wavelengths be customized?
Yes, fluorescent emission wavelengths can cover from ultraviolet to near-infrared bands, supporting single-color or multicolor fluorescence design, meeting multiplex labeling and multichannel detection needs.
Is surface functionalization possible?
Yes. We provide various surface functional group modifications such as carboxyl, amino, PEG, antibodies, nucleic acids, enabling targeted recognition and multifunctional extension.
How is biocompatibility of fluorescent nanoparticles ensured?
Biocompatibility is enhanced through surface functionalization and careful material selection, improving water solubility and biological compatibility to ensure suitability for in vivo and in vitro biomedical applications.
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