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7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid | 244636-14-4
| Catalog Number | F06-0005 |
| Category | Coumarin |
| Molecular Formula | C12H11NO7S |
| Molecular Weight | 313.29 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F06-0005 | -- | $-- |
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Product Introduction
7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid is a potent fluorescent probe utilized in the biomedical industry. It finds applications in the study of various drugs and diseases. It is commonly employed as a sensitive detection tool for drug metabolism, cellular activity, and receptor interactions. This acid is particularly useful in the assessment of drugs affecting the renin-angiotensin system and in research related to cancer therapeutics, particularly in studies of drug delivery systems and tumor targeting.
Chemical Information |
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|---|---|
| Synonyms | Alexa Fluor 350;2-Oxo-4-methyl-6-(hydroxysulfonyl)-7-amino-alpha-chromene-3-acetic acid |
| IUPAC Name | 2-(7-amino-4-methyl-2-oxo-6-sulfochromen-3-yl)acetic acid |
| Canonical SMILES | CC1=C(C(=O)OC2=CC(=C(C=C12)S(=O)(=O)O)N)CC(=O)O |
| InChI | InChI=1S/C12H11NO7S/c1-5-6-2-10(21(17,18)19)8(13)4-9(6)20-12(16)7(5)3-11(14)15/h2,4H,3,13H2,1H3,(H,14,15)(H,17,18,19) |
| InChI Key | LRPDYFRNVROAIN-UHFFFAOYSA-N |
- Product Specification
- Application
| Excitation | 340 |
| Emission | 440 |
| Storage | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. |
7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid, a fluorescent compound widely employed in biochemical contexts, serves various critical functions. Here are four key applications:
Fluorescence Microscopy: As an essential fluorescent probe in microscopy, this compound enables the visualization of intricate cellular and molecular structures. Its remarkable fluorescence efficiency facilitates the observation of proteins and molecules’ localization and dynamics within living cells. By selectively tagging targets with this vivid marker, scientists delve into cellular processes and interactions.
Enzyme Assays: Utilized as a substrate in enzyme assays, 7-Amino-4-methyl-6-sulfocoumarin-3-acetic acid monitors enzymatic activity with finesse. Upon enzymatic cleavage, it emits a distinctive fluorescent signal, quantitatively revealing enzyme kinetics and inhibitor effects. This application is particularly valuable in drug discovery and development realms, where manipulating enzyme activity holds substantial importance.
High-Throughput Screening: A cornerstone of drug discovery, this compound finds its place in high-throughput screening assays to identify potential drug candidates swiftly. Its fluorescent nature enables the swift and sensitive detection of biochemical reactions across numerous samples simultaneously. Employing this compound in screening libraries allows researchers to efficiently pinpoint compounds showcasing desired biological activities, streamlining the discovery process.
Analytical Biochemistry: In the domain of analytical biochemistry, this fluorescent compound plays a pivotal role in detecting and quantifying a myriad of biomolecules. Integrated into assays, it accurately measures concentrations of nucleic acids, proteins, and metabolites. This application is indispensable for both research and clinical diagnostics, providing a robust method for the meticulous analysis of biomolecules, guiding scientific inquiry and medical treatment decisions.
Applications of Fluorescent Probes & Dyes
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