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Product Introduction
Blue emitting Coumarin 343 dye can form a FRET pair with fluorescein (FAM). An amine reactive form, activated NHS ester. This amine-reactive NHS ester contains an aminohexanoyl linker between the fluorophore, and the reactive group. This linker provides better solubility and spatial separation between the fluorophore, and the target molecule being labeled.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms |
Coumarin 343 X NHS |
| Purity |
NMR 1H, HPLC-MS (95%) |
| IUPAC Name |
(2,5-dioxopyrrolidin-1-yl) 6-[(4-oxo-3-oxa-13-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1,5,7,9(17)-tetraene-5-carbonyl)amino]hexanoate |
| Canonical SMILES |
C1CC2=C3C(=C4C(=C2)C=C(C(=O)O4)C(=O)NCCCCCC(=O)ON5C(=O)CCC5=O)CCCN3C1 |
| InChI |
InChI=1S/C26H29N3O7/c30-20-9-10-21(31)29(20)36-22(32)8-2-1-3-11-27-25(33)19-15-17-14-16-6-4-12-28-13-5-7-18(23(16)28)24(17)35-26(19)34/h14-15H,1-13H2,(H,27,33) |
| InChIKey |
UTYUORAKIFFNAS-UHFFFAOYSA-N |
| Solubility |
good in DCM, DMSO, DMF |
| Appearance |
yellow solid |
| ε, L⋅mol-1⋅cm-1 |
39000 |
| Fluorescence Quantum Yield |
0.63 |
| Excitation |
437 |
| Emission |
477 |
| Storage |
12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| XLogP3 |
2.9 |
| Hydrogen Bond Donor Count |
1 |
| Hydrogen Bond Acceptor Count |
8 |
| Rotatable Bond Count |
9 |
| Exact Mass |
495.20055027 g/mol |
| Monoisotopic Mass |
495.20055027 g/mol |
| Topological Polar Surface Area |
122Ų |
| Heavy Atom Count |
36 |
| Formal Charge |
0 |
| Complexity |
947 |
| Isotope Atom Count |
0 |
| Defined Atom Stereocenter Count |
0 |
| Undefined Atom Stereocenter Count |
0 |
| Defined Bond Stereocenter Count |
0 |
| Undefined Bond Stereocenter Count |
0 |
| Covalently-Bonded Unit Count |
1 |
| Compound Is Canonicalized |
Yes |
| Publication Number |
Title |
Priority Date |
| EP-1842923-A1 |
Methanesulfonylaminoindole derivatives and labeled oligonucleotide probes containing them. |
2006-02-20 |
| EP-1842923-B1 |
Methanesulfonylaminoindole derivatives and labeled oligonucleotide probes containing them |
2006-02-20 |
| US-2007196852-A1 |
Labeling reagent |
2006-02-20 |
| US-7759470-B2 |
Labeling reagent |
2006-02-20 |
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