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6-Fluorescein phosphoramidite | 204697-37-0
| Catalog Number | R10-0005 |
| Category | Fluorescein FAM |
| Molecular Formula | C46H58N3O10P |
| Molecular Weight | 843.94 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R10-0005 | -- | $-- |
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Product Introduction
6-Fluorescein phosphoramidite is prepared from 6-carboxyfluorescein derivatives and does not contain 4,4'-dimethoxytrityl (DMT) groups. It can only be added once at the 5'end to terminate the synthesis.
Chemical Information |
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|---|---|
| Synonyms | FAM Phosphoramidite, 6-Isomer; 6-FAM phosphoramidite; FAM phosphoramidite, 6-isomer; DyLight FAM-6 CEP; 5'(6)-FAM; 5'-6-Fluorescein phosphoramidite; 6-((6-(((2-Cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)hexyl)carbamoyl)-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-3',6'-diyl bis(2,2-dimethylpropanoate) |
| Purity | ≥90% |
| IUPAC Name | [6-[6-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyhexylcarbamoyl]-6'-(2,2-dimethylpropanoyloxy)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] 2,2-dimethylpropanoate |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCCCCCNC(=O)C1=CC2=C(C=C1)C(=O)OC23C4=C(C=C(C=C4)OC(=O)C(C)(C)C)OC5=C3C=CC(=C5)OC(=O)C(C)(C)C)OCCC#N |
| InChI | InChI=1S/C46H58N3O10P/c1-29(2)49(30(3)4)60(55-25-15-22-47)54-24-14-12-11-13-23-48-40(50)31-16-19-34-37(26-31)46(59-41(34)51)35-20-17-32(56-42(52)44(5,6)7)27-38(35)58-39-28-33(18-21-36(39)46)57-43(53)45(8,9)10/h16-21,26-30H,11-15,23-25H2,1-10H3,(H,48,50) |
| InChI Key | MGPYJVWEJNTXLC-UHFFFAOYSA-N |
| Solubility | Soluble in Acetonitrile, DCM |
| Appearance | White to Off-white Solid |
| Boiling Point | 850.6±65.0°C at 760 mmHg |
- Product Specification
| ε, L⋅mol-1⋅cm-1 | 75000 |
| Fluorescence Quantum Yield | 0.9 |
| Excitation | 494 |
| Emission | 520 |
| Storage | Store at -20 °C |
Computed Properties | |
|---|---|
| XLogP3 | 8.5 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 21 |
| Exact Mass | 843.38598205 g/mol |
| Monoisotopic Mass | 843.38598205 g/mol |
| Topological Polar Surface Area | 163Ų |
| Heavy Atom Count | 60 |
| Formal Charge | 0 |
| Complexity | 1470 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2020256857-A1 | Universal histidine-tag binding compounds and methods of use thereof as fluorescent probes and sensors | 2014-04-29 |
| WO-2014120681-A2 | Optical element for correcting color blindness | 2013-01-29 |
| EP-2739997-B1 | Optical element for correcting color blindness | 2011-08-05 |
| US-2013032758-A1 | Optical Element for Correcting Color Blindness | 2011-08-05 |
| US-2013033776-A1 | Optical Element for Correcting Color Blindness | 2011-08-05 |
Applications of Fluorescent Probes & Dyes
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