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5-Carboxyfluorescein | 76823-03-5
| Catelog Number | F04-0024 |
| Category | Fluorescein FAM |
| Molecular Formula | C21H12O7 |
| Molecular Weight | 376.32 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| F04-0024 | -- | $-- |
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Product Introduction
5-Carboxyfluorescein is a derivative of fluorescein that can be used to label biomolecules through interacting with primary amines.
Chemical Information |
|
|---|---|
| Synonyms | 4-carboxyfluorescein; 5-FAM; 3',6'-Dihydroxy-3-oxo-3H-spiro[isobenzofuran-1,9'-xanthene]-5-carboxylic acid |
| Purity | ≥ 95 % |
| IUPAC Name | 3',6'-dihydroxy-3-oxospiro[2-benzofuran-1,9'-xanthene]-5-carboxylic acid |
| Canonical SMILES | C1=CC2=C(C=C1C(=O)O)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O |
| InChI | InChI=1S/C21H12O7/c22-11-2-5-15-17(8-11)27-18-9-12(23)3-6-16(18)21(15)14-4-1-10(19(24)25)7-13(14)20(26)28-21/h1-9,22-23H,(H,24,25) |
| InChI Key | NJYVEMPWNAYQQN-UHFFFAOYSA-N |
| Solubility | Soluble in DMF; Slightly soluble in DMSO, Methanol |
| Density | 1.73±0.1 g/cm3 (Predicted) |
| Appearance | Yellow solid |
| Boiling Point | 725.2±60.0 ℃ (Predicted) |
| Melting Point | 368-372 ℃ |
| MDL Number | MFCD00036874 |
| LogP | 3.36400 |
Product Specification |
|
|---|---|
| Excitation | 492 nm |
| Emission | 518 nm |
| Condition To Avoid | Light Sensitive |
| Storage | -20 ℃ |
| Signal | Warning |
| GHS Hazard Statements | H315 (20%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] |
| Precautionary Statement Codes | P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| XLogP3 | 2.9 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 1 |
| Exact Mass | 376.05830272 g/mol |
| Monoisotopic Mass | 376.05830272 g/mol |
| Topological Polar Surface Area | 113Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 637 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Literatures
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 22387888 | 2012-05-30 | Suppression of efflux transporters in the intestines of endotoxin-treated rats | International journal of pharmaceutics |
| 22545861 | 2012-05-16 | In vitro selection of functional lantipeptides | Journal of the American Chemical Society |
| 22276994 | 2012-04-20 | Cyclic peptide inhibitors of HIV-1 capsid-human lysyl-tRNA synthetase interaction | ACS chemical biology |
| 22272228 | 2012-01-01 | A reliable method for the selection of exploitable melanoma archival paraffin embedded tissues for transcript biomarker profiling | PloS one |
| 22295088 | 2012-01-01 | The kinetics of early T and B cell immune recovery after bone marrow transplantation in RAG-2-deficient SCID patients | PloS one |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-115192728-A | A kind of prodrug micelle and its preparation method and use | 2022-07-20 |
| CN-114805536-A | A kind of human platelet factor 4 protein mutant and its application | 2022-06-24 |
| CN-114805536-B | A kind of human platelet factor 4 protein mutant and its application | 2022-06-24 |
| CN-114807315-A | Method and application of Ψ-hybridization and Cas12a-assisted signal amplification to detect microRNA | 2022-06-21 |
| CN-115028716-A | A kind of monoclonal antibody and its application | 2022-06-10 |
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