6-AminoFluorescein | 51649-83-3

Product Introduction

6-AminoFluorescein is an indispensable fluorescent dye in the realm of biomedical research. Widely acknowledged for its paramount role in the genesis of diagnostic assays and biomolecule labeling, particularly nucleic acids and proteins, it unravels a new dimension in the detection and visualization of target molecules. Its acute sensitivity and harmonious compatibility render it a powerful tool in disease-related investigations pertaining to cancer diagnostics, pathogen identification, and drug discovery endeavors.

Chemical Information
Synonyms	6-Aminofluorescein (isomer II);6-AMINOFLUORESCEIN; 6-AMINO-3',6'-DIHYDROXYSPIRO[ISOBENZOFURAN-1(3H),9'-(9H)XANTHEN]-3-ONE; 6-amino-3',6'-dihydroxyspiro[isobenzofuran-1(3h),9'-[9h]xanthene]-3-one; AMINOFLUORESCEIN ISOMER II; 5-AMINOFLUORESCEIN (ISOMER II); FLUORESCEINAMINE, ISOMER 2
Purity	>95.0%(T)
IUPAC Name	5-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Canonical SMILES	C1=CC2=C(C=C1N)C3(C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O)OC2=O
InChI	InChI=1S/C20H13NO5/c21-10-1-4-13-16(7-10)20(26-19(13)24)14-5-2-11(22)8-17(14)25-18-9-12(23)3-6-15(18)20/h1-9,22-23H,21H2
InChI Key	YOAWSYSKQHLFPM-UHFFFAOYSA-N
Density	1.64 g/cm3
Appearance	Yellow Solid
Boiling Point	706.7ºC at 760 mmHg
Melting Point	285ºC (dec.)
MDL Number	MFCD00005051

Product Specification
Condition To Avoid	Light Sensitive
Storage	2-8ºC
Application	Fluorescent labeling reagent for proteins. Used in the fluorescent antibody technique for rapid identification of pathogens.
Signal	Warning
GHS Hazard Statements	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.)

Computed Properties
XLogP3	2.7
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	0
Exact Mass	347.07937252 g/mol
Monoisotopic Mass	347.07937252 g/mol
Topological Polar Surface Area	102Ų
Heavy Atom Count	26
Formal Charge	0
Complexity	557
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Literatures

PMID	Publication Date	Title	Journal
17683530	2007-08-02	Self assembly of amphiphilic C60 fullerene derivatives into nanoscale supramolecular structures	Journal of nanobiotechnology
1964628	1990-12-01	Potentiation of the antiviral activity of poly r(A-U) by xanthene dyes	Cell biology international reports

Patents

Publication Number	Title	Priority Date
CN-115040535-B	Application of Sulfated Hyaluronic Acid in Preparation of Eye Drops for Prevention of Corneal Fibrosis and Corneal Scar	2022-08-15
WO-2022207813-A1	Mitochondrial ph probes and uses thereof	2021-03-31
CN-113117172-A	Blood simulation medium and preparation method and application thereof	2021-03-29
CN-114755424-A	Supports, kits and methods for fluorescence polarization immunoassays	2021-01-08
US-2022221465-A1	Support for fluorescence polarization immunoassay, fluorescence polarization immunoassay kit and fluorescence polarization immunoassay	2021-01-08