Cholesterol TEG (DMT) Phosphoramidite (R) | CAS 1799625-61-8

Name: Cholesterol TEG (DMT) Phosphoramidite (R)
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R10-0046
Category	Phosphoramidites
Molecular Formula	C70H106N3O11P
Molecular Weight	1196.60

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Product Introduction

Cholesterol TEG (DMT) Phosphoramidite (R) is a non-fluorescent modifier used in oligonucleotide synthesis. It contains a cholesterol moiety attached to a phosphoramidite via a triethylene glycol (TEG) linker, with a dimethoxytrityl (DMT) protecting group, on an (R)-glycerol backbone. The TEG linker provides flexibility and hydrophilicity, while the DMT group enables standard trityl-on purification. Cholesterol conjugation enhances cellular uptake, improves nuclease resistance, and facilitates in vivo delivery of oligonucleotides.

Chemical Information

Chemical Information

Related CAS	873435-29-1 (Cholesterol TEG (DMT) Phosphoramidite)
Synonyms	1-Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite; Cholesteryl TEG phosphoramidite (R); Dimethoxytrityloxy-3-O-(N-cholesteryl-3-aminopropyl)triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)(N,N-diisopropyl)phosphoramidite; DMTr-Cholesteryl-TEG Phosphoramidite (R); 1-O-(4,4'-dimethoxytrityl)-3-O-(N-cholesteryl-3-aminopropyl)-triethyleneglycol-(R)-glyceryl-2-O-(2-cyanoethyl)-(N,N-diisopropyl) Phosphoramidite; DMT-Cholesterol (Plant) TEG CE phosphoramidite (R); Cholesterol (R)-Glycerol Phosphoramidite; Cholesterol TEG (DMT) (R)-Glycerol Phosphoramidite; (3S,8S,9S,10R,13R,14S,17R)-10,13-Dimethyl-17-((R)-6-methylheptan-2-yl)-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ((4R)-4-(((2-cyanoethoxy)(diisopropylamino)phosphaneyl)oxy)-1,1-bis(4-methoxyphenyl)-1-phenyl-2,6,9,12,15-pentaoxaoctadecan-18-yl)carbamate
SMILES	O=C(O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCCC(C)C)C)CC[C@@]4([H])[C@]3([H])CC=C2C1)NCCCOCCOCCOCCOC[C@@H](OP(OCCC#N)N(C(C)C)C(C)C)COC(C5=CC=C(OC)C=C5)(C6=CC=C(OC)C=C6)C7=CC=CC=C7
InChI	InChI=1S/C70H106N3O11P/c1-51(2)18-15-19-54(7)64-32-33-65-63-31-26-58-48-61(34-36-68(58,8)66(63)35-37-69(64,65)9)83-67(74)72-39-17-40-77-42-43-78-44-45-79-46-47-80-49-62(84-85(82-41-16-38-71)73(52(3)4)53(5)6)50-81-70(55-20-13-12-14-21-55,56-22-27-59(75-10)28-23-56)57-24-29-60(76-11)30-25-57/h12-14,20-30,51-54,61-66H,15-19,31-37,39-50H2,1-11H3,(H,72,74)/t54-,61+,62-,63+,64-,65+,66+,68+,69-,85?/m1/s1
InChIKey	FNJSTUYYFCEZCA-UDWAMZCPSA-N