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Netropsin | 1438-30-8
| Catalog Number | A19-0049 |
| Category | DNA Stains |
| Molecular Formula | C18H26N10O3 |
| Molecular Weight | 430.47 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A19-0049 | -- | $-- |
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Product Introduction
Netropsin is isolated from Streptomyces netropsis as a basic polypeptide. It can specific bind to A-T areas of DNA that is very useful to genetic research. Netropsin can disrupt the cell cycle, prolonging G and arresting in G. Netropsin has antibiotic and antiviral activity. It has been shown that Netropsin is active against Gram-positive and Gram-negative bacteria.
Chemical Information |
|
|---|---|
| Related CAS | 63770-20-7 (hydrochloride) |
| Synonyms | Antibiotic 1142; Antibiotic T-1384; Antibiotic T 1384; Sinanomycin; Congocidin; Congocidine; F6; F-9; IA-887; IA 887; K-117; K 117; N-(3-amino-3-iminopropyl)-4-(4-(2-guanidinoacetamido)-1-methyl-1H-pyrrole-2-carboxamido)-1-methyl-1H-pyrrole-2-carboxamide |
| Purity | ≥98% |
| Shelf Life | 2 years |
| IUPAC Name | N-[5-[(3-amino-3-iminopropyl)carbamoyl]-1-methylpyrrol-3-yl]-4-[[2-(diaminomethylideneamino)acetyl]amino]-1-methylpyrrole-2-carboxamide |
| Canonical SMILES | CN1C=C(C=C1C(=O)NC2=CN(C(=C2)C(=O)NCCC(=N)N)C)NC(=O)CN=C(N)N |
| InChI | InChI=1S/C18H26N10O3/c1-27-9-11(6-12(27)16(30)23-4-3-14(19)20)26-17(31)13-5-10(8-28(13)2)25-15(29)7-24-18(21)22/h5-6,8-9H,3-4,7H2,1-2H3,(H3,19,20)(H,23,30)(H,25,29)(H,26,31)(H4,21,22,24) |
| InChI Key | IDBIFFKSXLYUOT-UHFFFAOYSA-N |
| Density | 1.3374 g/cm3 |
| Appearance | Solid Powder |
| Boiling Point | 760.5°C at 760 mmHg |
| Melting Point | 171-173°C |
- Product Specification
| Storage | Store at -20°C |
| Signal | Danger |
| GHS Hazard Statements | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral] |
| Precautionary Statement Codes | P264, P270, P301+P316, P321, P330, P405, and P501 (The corresponding statement to each P-code can be found at the GHS Classification page.) |
Computed Properties | |
|---|---|
| XLogP3 | -3.1 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 9 |
| Exact Mass | 430.21893473 g/mol |
| Monoisotopic Mass | 430.21893473 g/mol |
| Topological Polar Surface Area | 211Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 723 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| AU-2021106734-A4 | Control of nematodes | 2021-08-24 |
| WO-2023275715-A1 | Metabolites of selective androgen receptor modulators | 2021-06-30 |
| WO-2023277113-A1 | Humanized antibody capable of binding to heg1 protein | 2021-06-30 |
| WO-2023278377-A1 | Methods of treating cancer with a combination of a nonfucosylated anti-cd70 antibody and a cd47 antagonist | 2021-06-29 |
| WO-2022261296-A1 | Compounds that bind non-canonical g-quadruplex structures and methods of making and using the same | 2021-06-09 |
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