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HOE-S 785026 trihydrochloride
| Catalog Number | A19-0045 |
| Category | DNA Stains |
| Molecular Formula | C25H27Cl3N6O |
| Molecular Weight | 533.88 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
HOE-S 785026 is a blue fluorescent dye used to stain DNA.
Chemical Information
Product Specification
Application
Computed Properties
| Related CAS | 132869-83-1 (free base) |
| Synonyms | 3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol trihydrochloride; HOE-S 785026 (trihydrochloride) |
| IUPAC Name | 3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol;trihydrochloride |
| Canonical SMILES | CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=CC=C6)O.Cl.Cl.Cl |
| InChI | InChI=1S/C25H24N6O.3ClH/c1-30-9-11-31(12-10-30)18-6-8-21-23(15-18)29-25(27-21)17-5-7-20-22(14-17)28-24(26-20)16-3-2-4-19(32)13-16;;;/h2-8,13-15,32H,9-12H2,1H3,(H,26,28)(H,27,29);3*1H |
| InChIKey | ZWKREDJJELOWKN-UHFFFAOYSA-N |
| Storage | Store at -20°C |
HOE-S 785026 trihydrochloride, a selective sigma-2 receptor ligand, finds diverse applications in medical and biological research. Here are four key applications:
Cancer Research: In the realm of oncology, HOE-S 785026 trihydrochloride emerges as a potent tool for unraveling the intricacies of sigma-2 receptors in tumor cell proliferation and apoptosis. By scrutinizing its binding properties and impact on cancer cells, scientists pave the way for innovative therapeutic approaches targeting malignancies like breast and prostate cancer. This compound not only sheds light on the therapeutic potential of sigma-2 receptors, but also propels the quest for novel anti-cancer agents.
Neurological Studies: Delving into the enigmatic realm of neural processes and neurodegenerative ailments, researchers turn to HOE-S 785026 trihydrochloride to probe the involvement of sigma-2 receptors. This compound acts as a gateway to understanding receptor-mediated neuroprotection and neuroplasticity in debilitating conditions such as Alzheimer’s and Parkinson’s disease.
Drug Discovery: A cornerstone in the drug development landscape, HOE-S 785026 trihydrochloride serves as a catalyst for screening and identifying novel sigma-2 receptor ligands. By juxtaposing the efficacy of emerging compounds against this compound, researchers fine-tune drug candidates with heightened efficacy and specificity.
Pain Management Research: Peering into the intricate web of pain pathways, researchers explore the potential of HOE-S 785026 trihydrochloride in modulating pain perception through sigma-2 receptors. By investigating its interplay with other analgesics and its impact on pain pathways, scientists aim to unveil novel avenues for pain management, particularly in chronic pain conditions.
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 3 |
| Exact Mass | 532.131193 g/mol |
| Monoisotopic Mass | 532.131193 g/mol |
| Topological Polar Surface Area | 84.1Ų |
| Heavy Atom Count | 35 |
| Formal Charge | 0 |
| Complexity | 642 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 4 |
| Compound Is Canonicalized | Yes |
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