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Specific Fluorescent Stains
DNA Stains
HOE-S 785026 trihydrochloride

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HOE-S 785026 trihydrochloride

Catalog Number	A19-0045
Category	DNA Stains
Molecular Formula	C25H27Cl3N6O
Molecular Weight	533.88

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Product Introduction

The trihydrochloride form enhances solubility for consistent fluorescence performance. Ideal for DNA quantification and microscopy applications.

Chemical Information
Product Specification
Application
Computed Properties

Related CAS	132869-83-1 (free base)
Synonyms	3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol trihydrochloride; HOE-S 785026 (trihydrochloride)
IUPAC Name	3-[6-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-benzimidazol-2-yl]phenol;trihydrochloride
Canonical SMILES	CN1CCN(CC1)C2=CC3=C(C=C2)N=C(N3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=CC=C6)O.Cl.Cl.Cl
InChI	InChI=1S/C25H24N6O.3ClH/c1-30-9-11-31(12-10-30)18-6-8-21-23(15-18)29-25(27-21)17-5-7-20-22(14-17)28-24(26-20)16-3-2-4-19(32)13-16;;;/h2-8,13-15,32H,9-12H2,1H3,(H,26,28)(H,27,29);3*1H
InChIKey	ZWKREDJJELOWKN-UHFFFAOYSA-N

Storage

Store at -20°C

HOE-S 785026 trihydrochloride, a selective sigma-2 receptor ligand, finds diverse applications in medical and biological research. Here are four key applications:

Cancer Research: In the realm of oncology, HOE-S 785026 trihydrochloride emerges as a potent tool for unraveling the intricacies of sigma-2 receptors in tumor cell proliferation and apoptosis. By scrutinizing its binding properties and impact on cancer cells, scientists pave the way for innovative therapeutic approaches targeting malignancies like breast and prostate cancer. This compound not only sheds light on the therapeutic potential of sigma-2 receptors, but also propels the quest for novel anti-cancer agents.

Neurological Studies: Delving into the enigmatic realm of neural processes and neurodegenerative ailments, researchers turn to HOE-S 785026 trihydrochloride to probe the involvement of sigma-2 receptors. This compound acts as a gateway to understanding receptor-mediated neuroprotection and neuroplasticity in debilitating conditions such as Alzheimer’s and Parkinson’s disease.

Drug Discovery: A cornerstone in the drug development landscape, HOE-S 785026 trihydrochloride serves as a catalyst for screening and identifying novel sigma-2 receptor ligands. By juxtaposing the efficacy of emerging compounds against this compound, researchers fine-tune drug candidates with heightened efficacy and specificity.

Pain Management Research: Peering into the intricate web of pain pathways, researchers explore the potential of HOE-S 785026 trihydrochloride in modulating pain perception through sigma-2 receptors. By investigating its interplay with other analgesics and its impact on pain pathways, scientists aim to unveil novel avenues for pain management, particularly in chronic pain conditions.

Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Exact Mass	532.131193 g/mol
Monoisotopic Mass	532.131193 g/mol
Topological Polar Surface Area	84.1Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	642
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	4
Compound Is Canonicalized	Yes