Biotin-11-dUTP

Product Introduction

Biotin-11-dUTP, a nucleotide analog of utmost significance, serves as a valuable tool in the labeling and detection of DNA. Synthetically engineered through the linkage of biotin and deoxyuridine triphosphate (dUTP) nucleotide, it seamlessly integrates with the DNA replication process. This paves the way for the detection of biotin-labeled DNA with the aid of streptavidin-conjugated reporters. Through the biotin-11-dUTP labeling, scientists worldwide have been able to further unravel the intricate processes of DNA replication, DNA repair, and gene expression analysis.

Chemical Information
Synonyms	Biotin-X-5-aminoallyl-dUTP; γ-[N-(Biotin-6-amino-hexanoyl)]-5-aminoallyl-2'-deoxyuridine-5'-triphosphate, Triethylammonium salt
Purity	≥ 95% by HPLC
IUPAC Name	[[(2R,3S,5R)-5-[5-[(E)-3-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]prop-1-enyl]-2,4-dioxopyrimidin-1-yl]-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate
Canonical SMILES	C1C(C(OC1N2C=C(C(=O)NC2=O)C=CCNC(=O)CCCCCNC(=O)CCCCC3C4C(CS3)NC(=O)N4)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI	InChI=1S/C28H45N6O17P3S/c35-19-13-24(49-20(19)15-48-53(44,45)51-54(46,47)50-52(41,42)43)34-14-17(26(38)33-28(34)40)7-6-12-30-22(36)9-2-1-5-11-29-23(37)10-4-3-8-21-25-18(16-55-21)31-27(39)32-25/h6-7,14,18-21,24-25,35H,1-5,8-13,15-16H2,(H,29,37)(H,30,36)(H,44,45)(H,46,47)(H2,31,32,39)(H,33,38,40)(H2,41,42,43)/b7-6+/t18-,19-,20+,21-,24+,25-/m0/s1
InChI Key	AZRNEVJSOSKAOC-VPHBQDTQSA-N
Solubility	Soluble in water
Appearance	sterile clear aqueous solution, in 10 mM Tris-HCl

Product Specification
Storage	Storage: 12 months after receival at -20 °C in the Dark. Transportation: at room temperature for up to 3 weeks. Avoid excessive freeze-thaw cycles.

Computed Properties
XLogP3	-4.5
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	22
Exact Mass	862.17747615 g/mol
Monoisotopic Mass	862.17747615 g/mol
Topological Polar Surface Area	363Ų
Heavy Atom Count	55
Formal Charge	0
Complexity	1650
Isotope Atom Count	0
Defined Atom Stereocenter Count	6
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	1
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
US-2018155767-A1	Methods of nucleic acid sample preparation for immune repertoire sequencing
US-10947582-B2	Methods of nucleic acid sample preparation for immune repertoire sequencing
US-2021180118-A1	Methods of nucleic acid sample preparation for immune repertoire sequencing
US-10704082-B2	Methods of nucleic acid sample preparation
US-2018127806-A1	Methods of nucleic acid sample preparation