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Alkyne dT phosphoramidite
| Catalog Number | A19-0080 |
| Category | DNA Stains |
| Molecular Formula | C48H56N5O9P |
| Molecular Weight | 877.96 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
This reagent is designed for the synthesis of oligonucleotides bearing triple bond (alkyne) in the middle of the chain. Alkyne is attached to deoxyuridine fragment, and it does not interfere with the hybridization to the complementary strand. This allows to prepare modified oligonucleotide probes bearing fluorescent dyes, quenchers, and other fragments attached to the middle of the chain, by virtue of copper catalyzed Click chemistry reaction with various azides.,This phosphoramidite is solid, so it is easy to dispense and handle. It is compatible with the standard deblocking conditions.
Chemical Information
Product Specification
Computed Properties
| Purity | NMR 1H, NMR 31P, HPLC-MS |
| IUPAC Name | 5-[1-[(2R,5R)-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-5-methyloxolan-2-yl]-2,4-dioxopyrimidin-5-yl]pent-4-ynyl-oxo-(prop-2-ynylamino)azanium |
| Canonical SMILES | CC1C(CC(O1)N2C=C(C(=O)NC2=O)C#CCCC[N+](=O)NCC#C)OP(N(C(C)C)C(C)C)OCCC#N |
| InChI | InChI=1S/C26H37N6O6P/c1-7-14-28-31(35)15-10-8-9-12-22-18-30(26(34)29-25(22)33)24-17-23(21(6)37-24)38-39(36-16-11-13-27)32(19(2)3)20(4)5/h1,18-21,23-24H,8,10-11,14-17H2,2-6H3,(H-,28,29,33,34,35)/p+1/t21-,23?,24-,39?/m1/s1 |
| InChIKey | QUPDQSRQEDVHPT-IAWAGCJASA-O |
| Solubility | Good in acetonitrile, DCM |
| Appearance | Off white solid |
| Mass Spec M+ Increment | 437.1 |
| Storage | Storage: 12 months after receival at -20 °C in the Dark. Transportation: at room temperature for up to 3 weeks. Desiccate. |
| XLogP3 | 2 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 9 |
| Rotatable Bond Count | 15 |
| Exact Mass | 561.25904495 g/mol |
| Monoisotopic Mass | 561.25904495 g/mol |
| Topological Polar Surface Area | 136Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 1 |
| Complexity | 1090 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 2 |
| Undefined Atom Stereocenter Count | 2 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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