5'-DMS(O)MT-Amino-Modifier C6 | CAS 1173109-53-9

5'-DMS(O)MT-Amino-Modifier C6 is an oligonucleotide-compatible amino-functional linker designed for post-synthetic conjugation workflows, enabling the introduction of a primary amine handle onto nucleic acids for downstream labeling and bioconjugation. In typical molecular biology and chemical biology pipelines, this reagent is used to prepare modified oligos for fluorescent tagging, affinity reagent construction, or attachment to surfaces and biomaterials where an amino group provides a versatile coupling point.

1. Oligonucleotide Labeling

5'-DMS(O)MT-Amino-Modifier C6 supports fluorescent labeling strategies by providing an amino functional group on the modified oligonucleotide, which can be used to couple dyes, fluorophore-bearing linkers, or imaging tags through standard amine-reactive chemistries. Researchers use amino-modified DNA or RNA to generate labeled probes for fluorescence microscopy, fluorescence-based hybridization assays, and nucleic acid tracing workflows where the fluorophore is ultimately installed on the amine-bearing oligo.

2. Surface Immobilization

5'-DMS(O)MT-Amino-Modifier C6 is frequently used to create nucleic acid reagents for surface functionalization, including immobilized capture probes on assay plates, biosensor surfaces, and microarray formats. The introduced amino functionality enables robust attachment to appropriately activated solid supports, supporting workflows such as hybridization assays, nucleic acid capture experiments, and assay development for platforms that require stable probe presentation.

3. Bioconjugated Probe Construction

5'-DMS(O)MT-Amino-Modifier C6 enables construction of bioconjugated nucleic acid probes by introducing a primary amine on the oligonucleotide backbone for coupling to proteins, peptides, nanoparticles, or polymer carriers. Chemical biology teams use these conjugates to build modular imaging or detection reagents, including nucleic acid-payload constructs where the oligo serves as the recognition component and the amino handle provides a practical attachment point for the secondary functional moiety.

4. Diagnostic Reagent Development

5'-DMS(O)MT-Amino-Modifier C6 is used in the development of nucleic acid assay components where labeled or immobilized oligonucleotides must be assembled reproducibly for research diagnostics workflows. By incorporating an amino modifier into the probe design, teams can standardize downstream reagent assembly for hybridization-based assays, signal-generation formats, and multiplexing strategies that rely on consistent conjugation chemistry across probe lots.

5. Polymer And Hydrogel Conjugation

5'-DMS(O)MT-Amino-Modifier C6 also supports nucleic acid incorporation into polymeric and hydrogel materials by enabling amine-based coupling to functional polymer backbones or crosslinkable matrices. Materials scientists and bioassay developers use amino-modified oligos to create nucleic-acid-functional materials for localized hybridization, immobilized sensing elements, and engineered biomaterials where the oligonucleotide must be stably presented within a bulk or surface-localized scaffold.