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Biotin phosphoramidite (hydroxyprolinol)
| Catelog Number | R10-0002 |
| Category | DNA Stains |
| Molecular Formula | C51H71N6O8PS |
| Molecular Weight | 959.18 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R10-0002 | -- | $-- |
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Product Introduction
Non-nucleosidic modifier reagent for the synthesis of biotinylated oligos based on a hydroxyprolinol core. This phosphoramidite contains a dimethoxytrityl protective group for the purification of the resulting oligos on C18 cartridges, and reverse phase HPLC. This modifier reagent can be used to introduce biotin onto 5'-position, 3'-position (using universal CPG), and internal oligo sites. This amidite does not require special condensation and deprotection conditions.
Chemical Information |
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|---|---|
| Purity | NMR 1H, 31P, HPLC-MS (95%), functional testing in oligo synthesis |
| IUPAC Name | 5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[6-[(2R,4R)-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxy-2-ethylcyclopentyl]-6-oxohexyl]pentanamide |
| Canonical SMILES | CCC1CC(CC1C(=O)CCCCCNC(=O)CCCCC2C3C(CS2)NC(=O)N3)OP(N(C(C)C)C(C)C)OCCC#N |
| InChI | InChI=1S/C32H56N5O5PS/c1-6-24-19-25(42-43(41-18-12-16-33)37(22(2)3)23(4)5)20-26(24)28(38)13-8-7-11-17-34-30(39)15-10-9-14-29-31-27(21-44-29)35-32(40)36-31/h22-27,29,31H,6-15,17-21H2,1-5H3,(H,34,39)(H2,35,36,40)/t24-,25-,26?,27+,29?,31+,43?/m1/s1 |
| InChI Key | FAZGOTPUJGOLES-VETMYCSXSA-N |
| Solubility | good in MeCN, DCM, THF |
| Appearance | white powder |
Product Specification |
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|---|---|
| Storage | 12 months after receival at -20°C in the dark. Transportation: at room temperature for up to 2 weeks. Avoid prolonged exposure to light. Desiccate. |
Computed Properties | |
|---|---|
| XLogP3 | 4 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 21 |
| Exact Mass | 653.37397808 g/mol |
| Monoisotopic Mass | 653.37397808 g/mol |
| Topological Polar Surface Area | 158Ų |
| Heavy Atom Count | 44 |
| Formal Charge | 0 |
| Complexity | 970 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 4 |
| Undefined Atom Stereocenter Count | 3 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Applications of Fluorescent Probes & Dyes
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