Alkyne Phosphoramidite, 5'-terminal | 1417539-32-2

Catalog Number	R10-0001
Category	DNA Stains
Molecular Formula	C21H36N3O3P
Molecular Weight	409.50

Catalog Number	Size	Price	Quantity
R10-0001	--	$--

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Product Introduction

Phosphoramidite for the synthesis of oligonucleotides with 5'-terminal alkyne for Click Chemistry. This alkyne amidite has several advantages over 5'-hexynyl phosphoramidite, 5'-butynyl-CEP, and other 5'-terminal alkyne phosphoramidites. First, it is solid compound which is easier to handle and dispense. And due to its structure, it is also more stable in solution, and has longer shelf life

Chemical Information
Product Specification

Synonyms	Alkyne Phosphoramidite; N-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]hex-5-ynamide; Rel-2-cyanoethyl ((1r,4r)-4-(hex-5-ynamido)cyclohexyl) diisopropylphosphoramidite
Purity	NMR 1H (95%) and 31P, HPLC-MS
IUPAC Name	N-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]hex-5-ynamide
Canonical SMILES	CC(C)N(C(C)C)P(OCCC#N)OC1CCC(CC1)NC(=O)CCCC#C
InChI	InChI=1S/C21H36N3O3P/c1-6-7-8-10-21(25)23-19-11-13-20(14-12-19)27-28(26-16-9-15-22)24(17(2)3)18(4)5/h1,17-20H,7-14,16H2,2-5H3,(H,23,25)
InChI Key	FWCBAXQTOIUYTE-UHFFFAOYSA-N
Solubility	good in acetonitrile and dichloromethane
Appearance	colorless solid

Storage

24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate.

Computed Properties
XLogP3	3.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	12
Exact Mass	409.24942902 g/mol
Monoisotopic Mass	409.24942902 g/mol
Topological Polar Surface Area	74.6Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	548
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
US-2022396791-A1	RNAi Agents for Inhibiting Expression of Receptor for Advanced Glycation End-products, Compositions Thereof, and Methods of Use	2021-04-08
WO-2022216920-A1	Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use	2021-04-08