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Alkyne Phosphoramidite, 5'-terminal | CAS 1417539-32-2
| Catalog Number | R10-0001 |
| Category | DNA Stains |
| Molecular Formula | C21H36N3O3P |
| Molecular Weight | 409.50 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Phosphoramidite for the synthesis of oligonucleotides with 5'-terminal alkyne for Click Chemistry. This alkyne amidite has several advantages over 5'-hexynyl phosphoramidite, 5'-butynyl-CEP, and other 5'-terminal alkyne phosphoramidites. First, it is solid compound which is easier to handle and dispense. And due to its structure, it is also more stable in solution, and has longer shelf life
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | Alkyne Phosphoramidite; N-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]hex-5-ynamide; Rel-2-cyanoethyl ((1r,4r)-4-(hex-5-ynamido)cyclohexyl) diisopropylphosphoramidite |
| Purity | NMR 1H (95%) and 31P, HPLC-MS |
| IUPAC Name | N-[4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxycyclohexyl]hex-5-ynamide |
| Canonical SMILES | CC(C)N(C(C)C)P(OCCC#N)OC1CCC(CC1)NC(=O)CCCC#C |
| InChI | InChI=1S/C21H36N3O3P/c1-6-7-8-10-21(25)23-19-11-13-20(14-12-19)27-28(26-16-9-15-22)24(17(2)3)18(4)5/h1,17-20H,7-14,16H2,2-5H3,(H,23,25) |
| InChIKey | FWCBAXQTOIUYTE-UHFFFAOYSA-N |
| Solubility | good in acetonitrile and dichloromethane |
| Appearance | colorless solid |
| Storage | 24 months after receival at -20°C in the dark. Transportation: at room temperature for up to 3 weeks. Avoid prolonged exposure to light. Desiccate. |
| XLogP3 | 3.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 12 |
| Exact Mass | 409.24942902 g/mol |
| Monoisotopic Mass | 409.24942902 g/mol |
| Topological Polar Surface Area | 74.6Ų |
| Heavy Atom Count | 28 |
| Formal Charge | 0 |
| Complexity | 548 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2022396791-A1 | RNAi Agents for Inhibiting Expression of Receptor for Advanced Glycation End-products, Compositions Thereof, and Methods of Use | 2021-04-08 |
| WO-2022216920-A1 | Rnai agents for inhibiting expression of receptor for advanced glycation end-products, compositions thereof, and methods of use | 2021-04-08 |
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