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MeOSuc-AAPV-pNA | 70967-90-7
| Catalog Number | A18-0004 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C27H38N6O9 |
| Molecular Weight | 590.63 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0004 | -- | $-- |
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Product Introduction
MeOSuc-AAPV-pNA is a highly sensitive peptide substrate that is hydrolyzed by both human and mouse neutrophil elastase and PR3, but not cathepsin G or chymotrypsin. MeOSuc-AAPV-pNA is cleaved at 405-410 nm.
Chemical Information |
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|---|---|
| Synonyms | N-(4-methoxy-1,4-dioxobutyl)-L-alanyl-L-alanyl-L-prolyl-N-(4-nitrophenyl)-L-valinamide |
| Purity | ≥98% |
| IUPAC Name | methyl 4-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-3-methyl-1-(4-nitroanilino)-1-oxobutan-2-yl]carbamoyl]pyrrolidin-1-yl]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-4-oxobutanoate |
| Canonical SMILES | CC(C)C(C(=O)NC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2CCCN2C(=O)C(C)NC(=O)C(C)NC(=O)CCC(=O)OC |
| InChI | InChI=1S/C27H38N6O9/c1-15(2)23(26(38)30-18-8-10-19(11-9-18)33(40)41)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,30,38)(H,31,37)/t16-,17-,20-,23-/m0/s1 |
| InChI Key | VLVGCNNWNUERRZ-OSAZLGQLSA-N |
| Density | 1.30 g/cm3 |
| Appearance | White Solid |
| Boiling Point | 958.38°C at 760 mmHg |
| Melting Point | 203-205°C |
- Product Specification
- Application
| Storage | Store at -20°C |
MeOSuc-AAPV-pNA, a synthetic peptide substrate prominent in biochemical and molecular biology research, boasts diverse applications. Here are four key applications:
Enzyme Activity Assays: Widely utilized in enzyme assays, MeOSuc-AAPV-pNA serves as a crucial tool for evaluating the activity of proteases, particularly those within the chymotrypsin-like family. By quantifying the release of the p-nitroaniline (pNA) chromophore, researchers can discern enzymatic activity with exceptional sensitivity. This substrate proves invaluable for delving into enzyme kinetics and conducting inhibitor screening, shedding light on the intricate workings of proteolytic processes.
Drug Discovery: Within the realm of drug discovery, MeOSuc-AAPV-pNA plays a pivotal role in screening potential protease inhibitors. This substrate furnishes a dependable and quantifiable measure of protease activity, aiding in the identification of novel therapeutic compounds. Its utility extends to expediting the drug development pipeline through facilitating high-throughput screening assays, accelerating the quest for groundbreaking pharmaceutical advancements.
Biochemical Pathway Research: Delving into biochemical pathways involving serine proteases, researchers leverage MeOSuc-AAPV-pNA to probe intricate proteolytic processes and their regulation under varying physiological conditions. This substrate offers a gateway to in-depth exploration of protease-mediated pathways, potentially unveiling novel strategies for combating diseases associated with protease dysregulation. Its application holds promise for advancing our understanding of disease mechanisms and therapeutic interventions.
Quality Control in Enzyme Production: Embraced in the quality control protocols of enzyme production, MeOSuc-AAPV-pNA emerges as a linchpin for ensuring the reliability and potency of enzyme batches, particularly in the context of enzymes like chymotrypsin. By verifying the activity of enzyme batches through this substrate, manufacturers uphold the consistency and efficacy of their enzyme offerings. This meticulous quality control process is paramount for applications demanding precise enzymatic activities, such as pharmaceuticals and diagnostics, safeguarding the integrity of critical enzyme-based applications.
Applications of Fluorescent Probes & Dyes
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