7-Ethoxy-4-trifluoromethylcoumarin

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7-Ethoxy-4-trifluoromethylcoumarin

7-Ethoxy-4-trifluoromethylcoumarin | CAS 115453-82-2

Catalog Number A18-0068
Category Fluorescent Enzyme Substrates
Molecular Formula C12H9F3O3
Molecular Weight 258.19
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Product Introduction

7-Ethoxy-4-trifluoromethylcoumarin is a fluorogenic substrate for cytochrome P-450 to determine the enzymatic activity.

  • Chemical Information

  • Application

  • Computed Properties

  • Literatures

  • Patents

Synonyms 7-Ethoxy-4-(trifluoromethyl)coumarin; 7-ethoxy-4-(trifluoromethyl)-2H-chromen-2-one; 7-ethoxy-4-(trifluoromethyl)chromen-2-one
IUPAC Name 7-ethoxy-4-(trifluoromethyl)chromen-2-one
Canonical SMILES CCOC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F
InChI InChI=1S/C12H9F3O3/c1-2-17-7-3-4-8-9(12(13,14)15)6-11(16)18-10(8)5-7/h3-6H,2H2,1H3
InChIKey OLHOIERZAZMHGK-UHFFFAOYSA-N
Hydrogen Bond Donor Count 0
Hydrogen Bond Acceptor Count 6
Rotatable Bond Count 2
Exact Mass 258.05037863 g/mol
Monoisotopic Mass 258.05037863 g/mol
Topological Polar Surface Area 35.5Ų
Heavy Atom Count 18
Formal Charge 0
Complexity 362
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes
PMID Publication Date Title Journal
23850985 2013-09-01 Interactions of sesquiterpenes zederone and germacrone with the human cytochrome P450 system Toxicology in vitro : an international journal published in association with BIBRA
22888116 2012-11-01 Increase of human CYP1B1 activities by acidic phospholipids and kinetic deuterium isotope effects on CYP1B1 substrate oxidation Journal of biochemistry
21964418 2011-11-15 Characterization of inhibitory effects of perfluorooctane sulfonate on human hepatic cytochrome P450 isoenzymes: focusing on CYP2A6 Chemico-biological interactions
21659470 2011-09-01 Polymorphic variants of cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) exhibit altered rates of metabolism for bupropion and efavirenz: a charge-reversal mutation in the K139E variant (CYP2B6.8) impairs formation of a functional cytochrome p450-reductase complex The Journal of pharmacology and experimental therapeutics
21510666 2011-06-07 Structural analysis of mammalian cytochrome P450 2B4 covalently bound to the mechanism-based inactivator tert-butylphenylacetylene: insight into partial enzymatic activity Biochemistry
Publication Number Title Priority Date
WO-2021074162-A1 Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer 2019-10-14
WO-2021074167-A1 Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer 2019-10-14
TW-202128986-A Cellule souche humaine génétiquement modifiée exprimant une protéine cytochrome p450 2b6 humaine mutante et son utilisation dans le traitement du cancer 2019-10-14
EP-4045633-A1 Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer 2019-10-14
EP-4045634-A1 Genetically modified human stem cell expressing a mutant human cytochrome p450 2b6 protein and use thereof in the treatment of cancer 2019-10-14

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