7-HC-arachidonate | CAS 161180-11-6

Catalog Number	A18-0052
Category	Fluorescent Enzyme Substrates
Molecular Formula	C29H36O4
Molecular Weight	448.6

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Product Introduction

7-hydroxycoumarinyl Arachidonate is a fluorogrnic substrate for cPLA2. 7-hydroxycoumarinyl arachidonate is hydrolyzed by phospholipase to release the fluorescent moiety 7-hydroxycoumarin.

Chemical Information
Product Specification
Application

Synonyms	Umbelliferyl Arachidonate; 7-Hydroxycoumarinyl Arachidonate; 5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-oxo-2H-1-benzopyran-7-yl ester
Purity	≥98%
Canonical SMILES	CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC1=CC2=C(C=C1)C=CC(=O)O2
InChI	InChI=1S/C29H36O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-28(30)32-26-22-20-25-21-23-29(31)33-27(25)24-26/h6-7,9-10,12-13,15-16,20-24H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChIKey	SFTGFGOBCQCZDY-DOFZRALJSA-N

Excitation	335 nm
Emission	450 nm
Storage	Store at -20°C

7-HC-arachidonate is a bioactive lipid compound with significant potential in various bioscience applications. Here are some key applications of 7-HC-arachidonate:

Neuroscience Research: 7-HC-arachidonate is used in neuroscience studies to investigate its effects on neural signaling and neuroprotection. It plays a role in modulating synaptic transmission and can be used to study its impact on neural plasticity and neurodegenerative disorders. Researchers explore its potential in treating conditions like Alzheimer’s disease and other cognitive impairments.

Inflammatory Response Studies: This compound is valuable for research into inflammatory pathways due to its role in modulating inflammation. By studying 7-HC-arachidonate, scientists can gain insights into the mechanisms of inflammatory responses and develop new anti-inflammatory therapies. It’s particularly useful in understanding diseases characterized by chronic inflammation, such as arthritis.

Cancer Research: 7-HC-arachidonate shows promise in cancer research due to its influence on cell proliferation and apoptosis. Researchers use it to explore its potential as an anti-cancer agent by studying its effects on cancer cell lines. Understanding its molecular mechanisms can lead to the development of novel cancer treatments.

Lipid Metabolism Studies: This compound is essential for studying lipid metabolism and the biochemistry of fatty acid derivatives. It helps researchers understand how bioactive lipids interact with various enzymes and receptors within metabolic pathways. These insights are crucial for developing therapeutic strategies for metabolic disorders such as obesity and diabetes.