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coumarin-SAHA | 1260635-77-5
| Catalog Number | A18-0018 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C18H22N2O5 |
| Molecular Weight | 346.4 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0018 | -- | $-- |
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Product Introduction
Suberoylanilide hydroxamic acid (SAHA) is a histone deacetylase (HDAC) inhibitor. Coumarin-Suberoylanilide hydroxamic acid (c-SAHA) is a SAHA derivative where the anilino "cap" group is replaced by 7-amino-4-methylcoumarin to produce a fluorescent probe that competitively binds HDAC. coumarin-SAHA is used to determine binding affinities and dissociation off-rates of HDAC enzyme-inhibitor complexes.
Chemical Information |
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|---|---|
| Synonyms | Coumarin-Suberoylanilide Hydroxamic Acid; N1-hydroxy-N8-(4-methyl-2-oxo-2H-chromen-7-yl)-octanediamide |
| Purity | ≥98% |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CCCCCCC(=O)NO |
| InChI | InChI=1S/C18H22N2O5/c1-12-10-18(23)25-15-11-13(8-9-14(12)15)19-16(21)6-4-2-3-5-7-17(22)20-24/h8-11,24H,2-7H2,1H3,(H,19,21)(H,20,22) |
| InChI Key | YSRCADVJNRJJAV-UHFFFAOYSA-N |
| Appearance | Solid Powder |
- Product Specification
- Application
| Excitation | 325 nm |
| Emission | 400 nm |
| Storage | Store at -20°C |
Coumarin-SAHA, a hybrid molecule merging coumarin and SAHA (suberoylanilide hydroxamic acid), presents diverse applications in clinical and research domains.
Cancer Therapy: Investigated as a prospective anticancer agent, Coumarin-SAHA exhibits a dual mechanism of action. The coumarin moiety exerts cytotoxic effects complemented by SAHA’s role as a histone deacetylase (HDAC) inhibitor, inducing apoptosis in cancer cells. This hybrid molecule signifies a synergistic approach to combat various cancers, bolstering efficacy and specificity simultaneously.
Epigenetic Research: Emphasizing the HDAC inhibitory aspect, the SAHA component of Coumarin-SAHA proves invaluable for probing epigenetic alterations within cells. By thwarting HDAC enzymes, researchers delve into histone acetylation’s impact on gene expression and chromatin remodeling. Leveraging Coumarin’s fluorescence attributes enables dual utility for cellular imaging, enriching epigenetic inquiries.
Neurodegenerative Disease Study: Within the realm of neurodegenerative disorder investigation, Coumarin-SAHA showcases promise for conditions like Alzheimer’s and Parkinson’s. HDAC inhibition holds potential for modulating gene expression linked to neuroprotection and cognitive faculties. Coumarin’s blood-brain barrier transversal ability enhances compound delivery to neural tissues, augmenting neurodegenerative disease research.
Drug Screening: Coumarin-SAHA’s utility extends to high-throughput screening assays, facilitating the discovery of novel therapeutic agents. The compound’s dual-mode of action and fluorescence properties position it aptly for pinpointing potential histone deacetylase inhibitors and evaluating their impact on cell viability. This application accelerates drug development targeting epigenetic regulators and pivotal cellular processes, propelling pharmaceutical advancements.
Applications of Fluorescent Probes & Dyes
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