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Specific Fluorescent Stains
Fluorescent Enzyme Substrates
Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2

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Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2

Catalog Number	A18-0028
Category	Fluorescent Enzyme Substrates
Molecular Formula	C99H144N28O20S
Molecular Weight	2078.4

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Product Introduction

Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 is a fluorogenic substrate for matrix metalloproteinase-3 (MMP-3). Upon enzymatic cleavage by MMP-3 at Glu-Nva, EDANS is separated from the Dabcyl quencher and its fluorescence can be used to quantify MMP-3 activity.

Chemical Information
Product Specification
Application

Synonyms	N2-[4-[[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]amino]-1-oxobutyl]-L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-valyl-L-α-glutamyl-L-norvalyl-L-tryptophyl-L-arginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-alanyl-L-lysinamide
Purity	≥95%

Storage

Store at -20°C

Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2, a fluorogenic peptide substrate widely utilized in biochemical research, especially in the domain of protease studies, is renowned for its distinctive ability to emit a fluorescent signal upon cleavage by specific proteases. Explore below four key applications of this compound presented:

Protease Activity Assays: Esteemed for its capacity to illuminate a fluorescent beacon upon intricate cleavage by specific proteases, the Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 substrate stands as a cornerstone in protease activity assays. This substrate serves as a priceless instrument in quantifying the protease activity within multifaceted biological samples and enzymatic reactions. Researchers seamlessly monitor enzymatic activities in real-time, enabling high-throughput screening of protease inhibitors or activators with meticulous precision.

Drug Discovery: Within the vast landscape of drug discovery, this fluorogenic peptide substrate emerges as a pivotal element in the identification and refinement of potential drug candidates targeting proteases. Through evaluating the substrate’s intricate cleavage in the presence of experimental compounds, researchers gauge the efficacy of these compounds in restraining or modulating protease function. This application assumes a critical role in advancing treatments for conditions characterized by protease dysregulation, such as cancer and inflammation, propelling boundless frontiers in therapeutic strategies.

Biochemical Pathway Elucidation: Researchers intricately weave this substrate into studies aimed at unraveling biochemical pathways intertwined with proteases. By astutely scrutinizing the activity of proteases under diverse conditions, scientists methodically chart out the proteolytic pathways and their profound impact on cellular processes.

Clinical Diagnostics: Dabcyl-GABA-RPKPVE-Nva-WR-Glu(EDANS)-AK-NH2 finds an illustrious role in clinical diagnostic assays designed to detect protease activity entwined with specific diseases. The luminous fluorescence sparked upon the cleavage of the substrate emerges as a priceless biomarker for conditions like infectious diseases and cancer, enabling the early detection of diseases and the ongoing monitoring of their progression. This innovative approach elevates patient care and treatment outcomes by furnishing timely insights into disease pathology.