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Dabcyl-RGVVNASSRLA-EDANS trifluoroacetate salt
| Catalog Number | A18-0054 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C73H109N23O18S·CF3COOH |
| Molecular Weight | 1628.9 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0054 | -- | -- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Dabcyl-RGVVNASSRLA-EDANS is a fluorogenic substrate for human cytomegalovirus (HCMV) protease. EDANS is released upon enzymatic cleavage by HCMV protease at the Ala-Ser site, of which the fluorescence can be used to quantify HCMV protease activity.
Chemical Information
Product Specification
Application
| Synonyms | Fluorogenic Human CMV Protease Substrate; N2-[4-[2-[4-(dimethylamino)phenyl]diazenyl]benzoyl]-L-arginylglycyl-L-valyl-L-valyl-L-asparaginyl-L-alanyl-L-seryl-L-seryl-L-arginyl-L-leucyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-alaninamide trifluoroacetate salt |
| Purity | ≥95% |
| Storage | Store at -20°C |
Dabcyl-RGVVNASSRLA-EDANS trifluoroacetate salt, a FRET (Förster Resonance Energy Transfer) peptide substrate crucial for biochemical assays and research, finds diverse applications in scientific endeavors.
Protease Activity Assays: Widely adopted in fluorescence-based assays, this compound serves as a pivotal tool for monitoring protease activity. When a protease cleaves the peptide between the Dabcyl (quencher) and EDANS (fluorophore) moieties, it triggers a surge in fluorescence signal, enabling researchers to precisely quantify protease activity and scrutinize enzyme kinetics with exceptional sensitivity.
Drug Screening: In the realm of pharmaceutical exploration, Dabcyl-RGVVNASSRLA-EDANS trifluoroacetate salt plays a significant role in high-throughput screening of potential therapeutic agents. By incorporating this peptide substrate into assays, researchers can pinpoint inhibitors or modulators of specific proteases, catalyzing the discovery of novel drugs tailored to combat diseases where protease activity plays a pivotal role.
Molecular Biology Research: Esteemed by researchers studying diverse biological processes involving proteolytic cleavage, this FRET-based substrate sheds light on the functions of specific proteases within cellular pathways. This substrate aids in unraveling disease mechanisms by facilitating real-time monitoring of cleavage events, offering invaluable insights into the dynamic changes occurring at a molecular level.
Biotechnological Applications: Leveraging this substrate in the realm of biosensors for diagnostic purposes, researchers enhance the capability to detect specific proteases in biological samples with heightened precision. By integrating this compound into sensor platforms, the presence of target proteases can be swiftly identified, paving the way for swift and sensitive protease detection in clinical settings and environmental monitoring tasks.
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