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Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 | CAS 150956-92-6
| Catalog Number | A18-0031 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C49H68N14O12S |
| Molecular Weight | 1077.23 |
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Product Introduction
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 is a synthetic peptide compound known for its role in biochemical research and development. This peptide features a complex structure that includes an N-terminal Dnp group and a C-terminal amide, contributing to its unique properties in peptide synthesis and analysis. The presence of modified amino acids such as Cys(Me) and K(Nma) enhances its stability and functionality in various experimental settings. Researchers utilize this compound to explore protein interactions, enzyme activity, and molecular signaling pathways.
Chemical Information
Product Specification
Application
| Synonyms | Matrix Metalloproteinase-1/Matrix Metalloproteinase-9 Fluorogenic Substrate; MMP-1/MMP-9 Fluorogenic Substrate; 1-(2,4-dinitrophenyl)-L-prolyl-3-cyclohexyl-L-alanylglycyl-S-methyl-L-cysteinyl-L-histidyl-L-alanyl-N6-[2-(methylamino)benzoyl]-L-lysinamide |
| Purity | ≥95% |
| IUPAC Name | (2S)-N-[(2S)-1-[[2-[[(2R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-6-[[2-(methylamino)benzoyl]amino]-1-oxohexan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methylsulfanyl-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-3-cyclohexyl-1-oxopropan-2-yl]-1-(2,4-dinitrophenyl)pyrrolidine-2-carboxamide |
| Canonical SMILES | CC(C(=O)NC(CCCCNC(=O)C1=CC=CC=C1NC)C(=O)N)NC(=O)C(CC2=CN=CN2)NC(=O)C(CSC)NC(=O)CNC(=O)C(CC3CCCCC3)NC(=O)C4CCCN4C5=C(C=C(C=C5)[N+](=O)[O-])[N+](=O)[O-] |
| InChI | InChI=1S/C49H68N14O12S/c1-29(44(66)58-35(43(50)65)16-9-10-20-53-45(67)33-14-7-8-15-34(33)51-2)56-47(69)37(23-31-25-52-28-55-31)59-48(70)38(27-76-3)57-42(64)26-54-46(68)36(22-30-12-5-4-6-13-30)60-49(71)40-17-11-21-61(40)39-19-18-32(62(72)73)24-41(39)63(74)75/h7-8,14-15,18-19,24-25,28-30,35-38,40,51H,4-6,9-13,16-17,20-23,26-27H2,1-3H3,(H2,50,65)(H,52,55)(H,53,67)(H,54,68)(H,56,69)(H,57,64)(H,58,66)(H,59,70)(H,60,71)/t29-,35-,36-,37-,38-,40-/m0/s1 |
| InChIKey | FLNOECDMJTUEJM-HAHFRGJSSA-N |
| Density | 1.341±0.06 g/cm3 |
| Boiling Point | 1490.5±65.0 °C at 760 mmHg |
| Storage | Store at -20°C |
Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2, a synthetic peptide with versatile applications in research and therapy, holds immense promise. Here are four key applications of this peptide:
Fluorescence-based Assays: Delving into the realm of protein-protein interactions, Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 shines as a beacon in fluorescence-based assays. Its fluorescent tag enables real-time tracking and quantification of binding events, unveiling the intricate dynamics and affinities underlying molecular interactions within biological systems.
Drug Development: With its intricate structure, Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 emerges as a frontrunner in peptide-based drug development. Scientists can tweak the peptide sequence to bolster stability, specificity, and efficacy, paving the way for novel therapeutics targeting specific pathways or receptors with precision and finesse.
Molecular Probes: Unleashing its potential as a molecular probe, this peptide transforms bioanalytical techniques like fluorescence resonance energy transfer (FRET) and surface plasmon resonance (SPR). Integrated into these platforms, it facilitates the sensitive detection and measurement of biomolecular interactions, offering invaluable insights for diagnostic applications and meticulous drug screening processes.
Enzyme Substrate Studies: Embracing the role of a versatile enzyme substrate, Dnp-P-Cha-G-Cys(Me)-HA-K(Nma)-NH2 immerses itself in enzyme kinetics and inhibition studies. By monitoring the cleavage or modification of the peptide, scientists unravel the nuances of enzyme activity and specificity, unlocking key details essential for characterizing enzymes and pinpointing potential inhibitors crucial for therapeutic advancements.
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