Azido-PEG9-amine

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Azido-PEG9-amine

Azido-PEG9-amine | 1207714-69-9

Catalog Number R14-0262
Category Azides
Molecular Formula C20H42N4O9
Molecular Weight 482.58
Catalog Number Size Price Quantity
R14-0262 -- $--

Product Introduction

Azido-PEG9-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 9 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Information

Synonyms N3-PEG9-CH2CH2NH2; Azido-PEG9-NH2; N3-PEG9-NH2; 29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosan-1-amine; 1-Amino-29-azido-3,6,9,12,15,18,21,24,27-nonaoxanonacosane
Purity ≥95%
Shelf Life 0-4°C for short term (days to weeks), or -20°C for long term (months).
IUPAC Name 2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES C(COCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI InChI=1S/C20H42N4O9/c21-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-20-18-32-16-14-30-12-10-28-8-6-26-4-2-23-24-22/h1-21H2
InChI Key QECAUUOGHAUEDJ-UHFFFAOYSA-N
Solubility Soluble in DCM, DMF, DMSO, Water
Appearance Colorless Oily Matter
LogP -3.23
  • Product Specification
Storage Store at 2-8°C

Computed Properties

XLogP3 -1.1
Hydrogen Bond Donor Count 1
Hydrogen Bond Acceptor Count 12
Rotatable Bond Count 29
Exact Mass 482.29517893 g/mol
Monoisotopic Mass 482.29517893 g/mol
Topological Polar Surface Area 123Ų
Heavy Atom Count 33
Formal Charge 0
Complexity 419
Isotope Atom Count 0
Defined Atom Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Bond Stereocenter Count 0
Covalently-Bonded Unit Count 1
Compound Is Canonicalized Yes

Patents

Publication NumberTitlePriority Date
WO-2020229982-A1 Antibody drug conjugates 2019-05-10
US-2022409734-A1 Antibody drug conjugates 2019-05-10
US-2005153371-A1 Conjugated small molecules 2004-01-07
US-2010048890-A1 Conjugated small molecules 2004-01-07
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