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Azido-PEG8-NHS ester | 1204834-00-3
| Catelog Number | R14-0316 |
| Category | Azides |
| Molecular Formula | C23H40N4O12 |
| Molecular Weight | 564.58 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0316 | -- | $-- |
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Product Introduction
Azido-PEG8-NHS ester is a cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG8-NHS ester is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical Information |
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|---|---|
| Related CAS | 1108750-59-9 (polymer) |
| Synonyms | Azido-PEG8-CH2CO2-NHS; N3-PEG8-C2-NHS ester; N3-PEG8-CH2CH2COONHS Ester; 1-[(1-Azido-27-oxo-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(27-azido-1-oxo-4,7,10,13,16,19,22,25-octaoxaheptacos-1-yl)oxy]-; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid succinimidyl ester |
| Purity | ≥95% |
| Shelf Life | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C23H40N4O12/c24-26-25-4-6-32-8-10-34-12-14-36-16-18-38-20-19-37-17-15-35-13-11-33-9-7-31-5-3-23(30)39-27-21(28)1-2-22(27)29/h1-20H2 |
| InChI Key | AZXJVYAMFTUKFC-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO (10 mm) |
| Appearance | Pale Yellow or Colorless Oily Liquid |
Product Specification |
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|---|---|
| Storage | Store at 2-8°C |
Computed Properties | |
|---|---|
| XLogP3 | -1.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 14 |
| Rotatable Bond Count | 29 |
| Exact Mass | 564.26427272 g/mol |
| Monoisotopic Mass | 564.26427272 g/mol |
| Topological Polar Surface Area | 152Ų |
| Heavy Atom Count | 39 |
| Formal Charge | 0 |
| Complexity | 693 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| EP-3619216-A1 | Rapamycin analogs as mtor inhibitors | 2017-05-02 |
| WO-2018204416-A1 | Rapamycin analogs as mtor inhibitors | 2017-05-02 |
| US-2021094975-A1 | Rapamycin analogs as mtor inhibitors | 2017-05-02 |
| AU-2018249559-A1 | Trifunctional constructs with tunable pharmacokinetics useful in imaging and anti-tumor therapies | 2017-04-05 |
| CN-110612126-A | Trifunctional constructs with tunable pharmacokinetics for imaging and antitumor therapy | 2017-04-05 |
Applications of Fluorescent Probes & Dyes
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