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Azido-PEG2-hydrazide-Boc | CAS 2100306-56-5
| Catalog Number | R14-0249 |
| Category | Azides |
| Molecular Formula | C12H23N5O5 |
| Molecular Weight | 317.35 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG2-hydrazide-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical Information
Product Specification
Application
| Synonyms | Azido-PEG2-t-Boc-hydrazide;Azido-PEG2-t-Boc-Hydrazide; tert-butyl 2-(3-(2-(2-azidoethoxy)ethoxy)propanoyl)hydrazine-1-carboxylate; Hydrazinecarboxylic acid, 2-[3-[2-(2-azidoethoxy)ethoxy]-1-oxopropyl]-, 1,1-dimethylethyl ester; 2-Methyl-2-propanyl 2-{3-[2-(2-azidoethoxy)ethoxy]propanoyl}hydrazinecarboxylate; Propanoic acid, 3-[2-(2-azidoethoxy)ethoxy]-, 2-[(1,1-dimethylethoxy)carbonyl]hydrazide |
| Purity | ≥95% |
| IUPAC Name | tert-butyl N-[3-[2-(2-azidoethoxy)ethoxy]propanoylamino]carbamate |
| Canonical SMILES | CC(C)(C)OC(=O)NNC(=O)CCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C12H23N5O5/c1-12(2,3)22-11(19)16-15-10(18)4-6-20-8-9-21-7-5-14-17-13/h4-9H2,1-3H3,(H,15,18)(H,16,19) |
| InChIKey | JYNHRXFEKXQQDG-UHFFFAOYSA-N |
| Appearance | Light Yellow Oily Matter |
| Storage | Store at 2-8°C |
Azido-PEG2-hydrazide-Boc, a versatile chemical reagent with diverse applications in bioconjugation and chemical biology, is at the forefront of cutting-edge research. Here are four key applications of Azido-PEG2-hydrazide-Boc presented in a high degree of perplexity and burstiness:
Protein Labeling: Serving as a pivotal tool in protein labeling, Azido-PEG2-hydrazide-Boc facilitates the precise attachment of fluorescent tags or other reporting molecules to proteins. The azide group’s involvement in click chemistry reactions offers an efficient avenue for conjugating biomolecules, unveiling the intricate dynamics of protein interactions within diverse biological systems. This innovative approach sheds light on the complexities of cellular processes, opening new avenues for exploration into protein dynamics.
Drug Delivery Systems: Researchers leverage the versatility of Azido-PEG2-hydrazide-Boc to design targeted drug delivery systems by conjugating the compound with therapeutic molecules. This strategic integration results in prodrugs that can be activated selectively in specific cellular environments, enhancing drug specificity while minimizing off-target effects. Such tailored drug delivery systems have the potential to revolutionize therapeutic outcomes, heralding a new era of precision medicine with enhanced efficacy and reduced side effects.
Nanoparticle Functionalization: Azido-PEG2-hydrazide-Boc plays a crucial role in the functionalization of nanoparticles for biomedical applications, enhancing their stability and biocompatibility through PEGylation. Its versatility, combined with the azide group, allows for additional conjugation with targeting ligands or therapeutic agents, propelling the field of nanomedicine into new realms of diagnostics and treatment. This comprehensive approach sets the stage for personalized nanoparticle-based therapies in the evolving landscape of precision medicine.
Biochemical Assays: In the realm of biochemical assays, Azido-PEG2-hydrazide-Boc stands out as a fundamental component in creating chemically reactive surfaces or beads for capturing and immobilizing specific biomolecules through click chemistry. These modified surfaces drive the detection and analysis of various biological samples, optimizing high-throughput screening and diagnostic assays. The versatility and utility of Azido-PEG2-hydrazide-Boc underscore its essential role in advancing biochemical research and driving biotechnological innovation to new heights.
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