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Azido-PEG6-NHS ester | CAS 2055014-64-5
| Catalog Number | R14-0318 |
| Category | Azides |
| Molecular Formula | C19H32N4O10 |
| Molecular Weight | 476.48 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Related CAS | 1108750-59-9 (polymer) |
| Synonyms | Azido-PEG6-NHS;Azido-PEG6-CH2CO2-NHS; N3-PEG6-C2-NHS ester; N3-PEG6-CH2CH2COONHS Ester; 1-[(1-Azido-21-oxo-3,6,9,12,15,18-hexaoxahenicosan-21-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(21-azido-1-oxo-4,7,10,13,16,19-hexaoxaheneicos-1-yl)oxy]-; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate |
| Purity | ≥95% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C19H32N4O10/c20-22-21-4-6-28-8-10-30-12-14-32-16-15-31-13-11-29-9-7-27-5-3-19(26)33-23-17(24)1-2-18(23)25/h1-16H2 |
| InChIKey | WXKOAPGNZNSYPW-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, DMF, DMSO, Water |
| Appearance | Pale Yellow or Colorless Oily Liquid |
| Storage | Store at -20°C, keep in dry and avoid sunlight |
Azido-PEG6-NHS ester, a versatile reagent in bioconjugation and bioorthogonal chemistry, finds diverse applications. Here are four key uses showcased with high perplexity and burstiness:
Protein Labeling: Employing azido-PEG6-NHS ester in protein labeling involves the specific attachment of the azido group to lysine residues through amine-reactive NHS ester chemistry. Subsequently, these labeled proteins can undergo further conjugation with alkyne-functionalized molecules via click chemistry, facilitating a myriad of bioanalytical applications.
Drug Delivery: Azido-PEG6-NHS ester plays a pivotal role in crafting targeted drug delivery systems that enhance therapeutic efficacy and reduce off-target effects. By conjugating therapeutic molecules to this reagent and linking them with targeting moieties like antibodies or ligands, researchers refine the precision of drug delivery.
Biomaterials: Functionalizing biomaterials, such as hydrogels and nanoparticles, with azido groups using Azido-PEG6-NHS ester sets the stage for integrating various bioactive compounds through click chemistry. This integration enhances biocompatibility and functionality, particularly in the intricate realm of tissue engineering scaffolds and diagnostic devices, laying the groundwork for cutting-edge developments in regenerative medicine.
Imaging Probes: In the realm of molecular and cellular imaging, the synthesis of imaging probes using azido-PEG6-NHS ester opens new vistas for researchers. By attaching fluorescent dyes or radioactive isotopes to azido-PEG6-NHS ester-labeled biomolecules, researchers can unveil the dynamic tapestry of biological processes in real time, unlocking crucial insights into health and disease mechanisms in a vibrant display of scientific discovery.
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 23 |
| Exact Mass | 476.21184323 g/mol |
| Monoisotopic Mass | 476.21184323 g/mol |
| Topological Polar Surface Area | 133Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 599 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2020157087-A1 | Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer | 2018-11-20 |
| WO-2020106886-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| AU-2019385497-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| EP-3883610-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| KR-20210116437-A | Macrocyclic complexes of radionuclides and their use in radiation therapy of cancer | 2018-11-20 |
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