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Azido-PEG6-NHS ester | 2055014-64-5
| Catelog Number | R14-0318 |
| Category | Azides |
| Molecular Formula | C19H32N4O10 |
| Molecular Weight | 476.48 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0318 | -- | $-- |
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Product Introduction
Azido-PEG6-NHS ester is a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-NHS ester is also a PEG- and Alkyl/ether based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical Information |
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|---|---|
| Related CAS | 1108750-59-9 (polymer) |
| Synonyms | Azido-PEG6-NHS;Azido-PEG6-CH2CO2-NHS; N3-PEG6-C2-NHS ester; N3-PEG6-CH2CH2COONHS Ester; 1-[(1-Azido-21-oxo-3,6,9,12,15,18-hexaoxahenicosan-21-yl)oxy]-2,5-pyrrolidinedione; 2,5-Pyrrolidinedione, 1-[(21-azido-1-oxo-4,7,10,13,16,19-hexaoxaheneicos-1-yl)oxy]-; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate |
| Purity | ≥95% |
| Shelf Life | 0-4℃ for short term (days to weeks), or -20℃ for long term (months). |
| IUPAC Name | (2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C1CC(=O)N(C1=O)OC(=O)CCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C19H32N4O10/c20-22-21-4-6-28-8-10-30-12-14-32-16-15-31-13-11-29-9-7-27-5-3-19(26)33-23-17(24)1-2-18(23)25/h1-16H2 |
| InChI Key | WXKOAPGNZNSYPW-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, DMF, DMSO, Water |
| Appearance | Pale Yellow or Colorless Oily Liquid |
Product Specification |
|
|---|---|
| Storage | Store at -20°C, keep in dry and avoid sunlight |
Computed Properties | |
|---|---|
| XLogP3 | -0.8 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 23 |
| Exact Mass | 476.21184323 g/mol |
| Monoisotopic Mass | 476.21184323 g/mol |
| Topological Polar Surface Area | 133Ų |
| Heavy Atom Count | 33 |
| Formal Charge | 0 |
| Complexity | 599 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2020157087-A1 | Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer | 2018-11-20 |
| WO-2020106886-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| AU-2019385497-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| EP-3883610-A1 | Macrocyclic complexes of radionuclides and their use in radiotherapy of cancer | 2018-11-20 |
| KR-20210116437-A | Macrocyclic complexes of radionuclides and their use in radiation therapy of cancer | 2018-11-20 |
Applications of Fluorescent Probes & Dyes
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