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Azide-PEG1-Val-Cit-PABC-OH | 2055041-40-0
| Catalog Number | R14-0030 |
| Category | Azides |
| Molecular Formula | C23H36N8O6 |
| Molecular Weight | 520.58 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0030 | -- | $-- |
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Chemical Information |
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| Synonyms | Azido-PEG1-Val-Cit-PAB-OH;N3-PEG1-Val-Cit-PAB-OH |
| Purity | >98.0% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| Canonical SMILES | CC(C)C(C(=O)NC(CCCNC(=O)N)C(=O)NC1=CC=C(C=C1)CO)NC(=O)CCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C23H36N8O6/c1-15(2)20(30-19(33)9-12-37-13-11-27-31-25)22(35)29-18(4-3-10-26-23(24)36)21(34)28-17-7-5-16(14-32)6-8-17/h5-8,15,18,20,32H,3-4,9-14H2,1-2H3,(H,28,34)(H,29,35)(H,30,33)(H3,24,26,36)/t18-,20-/m0/s1 |
| InChI Key | BDMOXMNQSIHXBI-ICSRJNTNSA-N |
| Solubility | 10 mm in DMSO |
- Product Specification
- Application
| Storage | Store at -5°C,keep in dry and avoid sunlight. |
Azide-PEG1-Val-Cit-PABC-OH is a bifunctional compound utilized in targeted drug delivery and bioconjugation research. Here are some key applications of Azide-PEG1-Val-Cit-PABC-OH:
Antibody-Drug Conjugates (ADCs): Azide-PEG1-Val-Cit-PABC-OH is commonly used in the synthesis of ADCs, which are designed to selectively target and deliver cytotoxic drugs to cancer cells. The azide group enables click chemistry with alkyne-functionalized antibodies, facilitating efficient conjugation. This approach enhances the therapeutic index by minimizing off-target effects and maximizing drug delivery to tumor cells.
Prodrug Design: This compound can be employed in the development of prodrugs, where the spacer unit (PEG1-Val-Cit-PABC) is cleaved by specific enzymes in the target tissue. The cleavage releases the active drug precisely at the site of action, reducing systemic toxicity. This strategy is particularly useful for drugs with narrow therapeutic windows, providing localized therapy with improved safety profiles.
Bioconjugation Research: Azide-PEG1-Val-Cit-PABC-OH is a versatile linker in bioconjugation techniques, which are essential for attaching biomolecules to various surfaces or carriers. The azide group participates in click chemistry reactions, enabling efficient attachment to diverse functional groups. This property is valuable in generating bioconjugates for diagnostic applications, imaging, and therapeutic interventions.
Cellular Targeting: The compound can be applied in developing targeted delivery systems for intracellular drug delivery. By conjugating therapeutic agents to ligands that specifically bind to cellular receptors, Azide-PEG1-Val-Cit-PABC-OH facilitates receptor-mediated endocytosis. This enhances the intracellular concentration of the therapeutic agent, improving its efficacy in treating diseases like cancer and infectious diseases.
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