Azido-PEG8-propionic acid | CAS 1214319-92-2

Name: Azido-PEG8-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0283
Category	Azides
Molecular Formula	C19H37N3O10
Molecular Weight	467.51

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Product Introduction

Azido-PEG8-acid is a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Information
Product Specification
Application

Related CAS	1167575-20-3 (polymer)
Synonyms	Azido-PEG8-acid;N3-PEG8-COOH; Azido-PEG8-C2-acid; Azido-PEG8-Acid; N3-PEG8-CH2CH2COOH; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-oic acid; 3,6,9,12,15,18,21,24-Octaoxaheptacosan-27-oic acid, 1-azido-; Azido-dPEG(R)8-acid
Purity	≥95%
Shelf Life	0-4°C for short term (days to weeks), or -20°C for long term (months).
IUPAC Name	3-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
Canonical SMILES	C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)O
InChI	InChI=1S/C19H37N3O10/c20-22-21-2-4-26-6-8-28-10-12-30-14-16-32-18-17-31-15-13-29-11-9-27-7-5-25-3-1-19(23)24/h1-18H2,(H,23,24)
InChIKey	URUGOEBULOZLBF-UHFFFAOYSA-N
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Pale Yellow Oily Matter

Storage

Store at 2-8°C

Azido-PEG8-propionic acid, a versatile chemical compound with diverse applications, is widely utilized across scientific and industrial domains. Here are four key applications of Azido-PEG8-propionic acid:

Bioconjugation: Positioned at the forefront of bioconjugation techniques, Azido-PEG8-propionic acid serves as an essential element in linking biomolecules such as proteins, peptides, and antibodies through click chemistry reactions. The azide group’s strategic presence enables precise and efficient interactions with alkyne groups, culminating in the formation of stable triazole linkages.

Drug Delivery Systems: Azido-PEG8-propionic acid plays a pivotal role in advancing sophisticated drug delivery systems. The polyethylene glycol (PEG) linker elevates the solubility and stability of drug molecules, while the azide moiety facilitates attachment to other functional groups. This harmonious collaboration fosters the development of biocompatible and targeted delivery platforms, magnifying the efficacy and safety of therapeutic interventions through the seamless fusion of chemistry and pharmacology.

Surface Modification: Venturing into the realm of surface modification, Azido-PEG8-propionic acid finds its niche in enhancing surfaces of nanoparticles, medical implants, and biosensors. The azido group empowers surface functionalization through click chemistry, providing a versatile avenue to attach diverse biomolecules and polymers. These enhancements bolster the biocompatibility, functionality, and specificity of surfaces, tailoring them for precise and targeted applications across a spectrum of scientific and industrial frontiers.

Research Tool in Chemical Biology: Within the domain of chemical biology, Azido-PEG8-propionic acid emerges as an indispensable reagent for probing biological interactions and processes. It acts as a potent tool for labeling biomolecules with fluorescent or affinity tags, aiding in the visualization and purification of these entities. This capability, crucial for a myriad of applications spanning from dissecting protein-protein interactions to scrutinizing cellular components, underscores the compound’s pivotal role as a linchpin in unraveling the intricacies of chemical biology.