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Azidoethyl-SS-ethylazide | CAS 352305-38-5
| Catalog Number | R14-0020 |
| Category | Azides |
| Molecular Formula | C4H8N6S2 |
| Molecular Weight | 204.28 |
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Product Introduction
Chemical Information
Product Specification
Application
Computed Properties
Literatures
Patents
| Synonyms | 1,2-bis(2-azidoethyl)disulfane; bis(2-azidoethyl) disulfide; 1,6-Diazido-3,4-dithiahexane; 1-azido-2-(2-azidoethyldisulfanyl)ethane |
| Purity | >99.3% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | |
| Canonical SMILES | C(CSSCCN=[N+]=[N-])N=[N+]=[N-] |
| InChI | InChI=1S/C4H8N6S2/c5-9-7-1-3-11-12-4-2-8-10-6/h1-4H2 |
| InChIKey | SYKSDZXTWAVSIP-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Appearance | Solid |
| Storage | -20°C |
Azidoethyl-SS-ethylazide, a versatile bifunctional click chemistry reagent, finds widespread use in diverse biochemical and molecular biology applications. Here are four key applications of Azidoethyl-SS-ethylazide:
Protein Labeling: Harnessing the power of bioorthogonal click chemistry, Azidoethyl-SS-ethylazide serves as a vital tool for tagging proteins with reporter molecules such as fluorophores or affinity tags. This labeling strategy enables the visualization and purification of proteins within intricate biological samples. The exquisite specificity and efficiency of the azide-alkyne cycloaddition reaction guarantee minimal disruption to protein functionality, ensuring accurate analysis and manipulation.
Drug Delivery: In the realm of targeted drug delivery, Azidoethyl-SS-ethylazide plays a crucial role in conjugating therapeutic agents to specific targeting molecules like antibodies or peptides. By establishing connections between drugs and targeting moieties through click chemistry linkages, this compound facilitates the precise delivery of therapeutics to designated cells or tissues. This targeted delivery mechanism not only enhances the efficacy of treatments but also mitigates undesirable side effect.
Material Science: Embracing the realm of material science, Azidoethyl-SS-ethylazide emerges as a valuable asset for crafting functionalized materials such as hydrogels, nanoparticles, and polymers. By embedding azide groups into materials, researchers can achieve site-specific modifications and cross-linking via click chemistry reactions. This innovative technique is pivotal for the creation of advanced materials boasting tailored properties, facilitating applications across diverse sectors including biomedicine and industry.
DNA and RNA Probes: Delving into the realm of nucleic acid studies, Azidoethyl-SS-ethylazide proves instrumental in synthesizing DNA and RNA probes for investigating genetic material. Through its interaction with alkyne-modified nucleotides, this compound generates stable, covalently linked probes crucial for a range of biotechnological and diagnostic tools. These probes heighten the sensitivity and specificity of techniques like fluorescence in situ hybridization (FISH) and next-generation sequencing (NGS), enabling detailed insights into genetic material and molecular interactions.
| XLogP3 | 2.7 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 7 |
| Exact Mass | 204.02518663 g/mol |
| Monoisotopic Mass | 204.02518663 g/mol |
| Topological Polar Surface Area | 79.3Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 172 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| PMID | Publication Date | Title | Journal |
|---|---|---|---|
| 19883046 | 2009-12-14 | Macromolecular cobalt carbonyl complexes encapsulated in a click-cross-linked micelle structure as a nanoparticle to deliver cobalt pharmaceuticals | Biomacromolecules |
| Publication Number | Title | Priority Date |
|---|---|---|
| CN-114014852-A | A class of fluorescence-directed superoxide-enhanced photosensitizer dyes based on benzophenothiazine dimers, their preparation methods and applications | 2021-09-29 |
| EP-3565543-A1 | Mu opioid receptor modulators | 2017-01-06 |
| US-2020109126-A1 | Mu opioid receptor modulators | 2017-01-06 |
| US-10702498-B2 | MU opioid receptor modulators | 2015-07-09 |
| US-2019076398-A1 | Mu opioid receptor modulators | 2015-07-09 |
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