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Azido-PEG8-amine | 857891-82-8
| Catelog Number | R14-0263 |
| Category | Azides |
| Molecular Formula | C18H38N4O8 |
| Molecular Weight | 438.52 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0263 | -- | $-- |
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Product Introduction
Azido-PEG8-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. It is also a non-cleavable 8 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Chemical Information |
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|---|---|
| Synonyms | O-(2-Aminoethyl)-O'-(2-azidoethyl)heptaethylene glycol; N3-PEG8-CH2CH2NH2; Azido-PEG8-NH2; N3-PEG8-NH2; 26-Azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-amine |
| Purity | ≥90% |
| IUPAC Name | 2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine |
| Canonical SMILES | C(COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-])N |
| InChI | InChI=1S/C18H38N4O8/c19-1-3-23-5-7-25-9-11-27-13-15-29-17-18-30-16-14-28-12-10-26-8-6-24-4-2-21-22-20/h1-19H2 |
| InChI Key | ZSFGTBJYBWJOLZ-UHFFFAOYSA-N |
| Appearance | Colorless or Light Yellowish Liquid |
| LogP | 0.54126 |
Product Specification |
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|---|---|
| Storage | Store at 2-8°C |
| Signal | Warning |
| GHS Hazard Statements | H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 |
Computed Properties | |
|---|---|
| XLogP3 | -1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 11 |
| Rotatable Bond Count | 26 |
| Exact Mass | 438.26896418 g/mol |
| Monoisotopic Mass | 438.26896418 g/mol |
| Topological Polar Surface Area | 114Ų |
| Heavy Atom Count | 30 |
| Formal Charge | 0 |
| Complexity | 376 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022219409-A2 | Compositions containing nucleic acid nanoparticles and processes related to alteration of their physicochemical characteristics | 2021-04-15 |
| US-2022072141-A1 | Protein-drug conjugates comprising camptothecin analogs and methods of use thereof | 2020-07-13 |
| US-2021330810-A1 | Compositions containing nucleic acid nanoparticles with modular functionality | 2020-04-27 |
| US-11357865-B2 | Compositions containing nucleic acid nanoparticles with modular functionality | 2020-04-27 |
| US-2022370635-A1 | Compositions containing nucleic acid nanoparticles with modular functionality | 2020-04-27 |
Applications of Fluorescent Probes & Dyes
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