Azido-PEG7-alcohol | CAS 1274892-60-2

Azido-PEG7-alcohol is a PEG-based azide building block designed for copper-free and copper-mediated click chemistry workflows, enabling efficient bioorthogonal or orthogonal conjugation strategies. The reagent combines a terminal azide handle with a flexible PEG7 spacer and a primary alcohol functionality, which together support solubility, spacer-controlled presentation, and downstream functionalization for research-grade labeling and materials assembly. Its azide group is widely used as a partner for cycloaddition with complementary alkynes, making it a common choice for constructing PEGylated probes, surface linkers, and polymer conjugates in chemical biology and biomaterials development.

1. Bioorthogonal PEG Labeling

Azido-PEG7-alcohol is commonly used as a PEGylated azide linker to install flexible, hydrophilic spacers on biomolecular targets and synthetic constructs. Researchers employ it to generate labeling reagents for fluorescence, affinity, and activity-tracking studies where reduced nonspecific interactions and improved aqueous compatibility are important. The PEG7 chain helps tune effective probe size and accessibility of the conjugated moiety, while the terminal alcohol can serve as a handle for further derivatization into additional functional formats before or after the click step.

2. Surface And Material Conjugation

Azido-PEG7-alcohol is frequently incorporated into surface modification and materials chemistry workflows to create azide-functional interfaces for subsequent click attachment of dyes, targeting ligands, or imaging tags. The PEG spacer supports antifouling-like behavior and can improve the presentation of attached ligands on hydrogels, polymer films, and nanoparticle coatings by reducing steric crowding at the surface. The primary alcohol functionality provides a practical starting point for immobilization chemistries or for converting the reagent into more reactive derivatives suited to material processing.

3. Molecular Imaging Probe Building

Azido-PEG7-alcohol is used in molecular imaging reagent development as a modular azide component for assembling probe architectures that require controlled spacing between a reporter and a binding or recognition element. Probe designers leverage the PEG7 length to mitigate quenching, enhance solubility, and improve the accessibility of appended functional groups when constructing complex imaging conjugates. The azide handle enables reliable coupling to complementary alkyne-bearing reporters, while the alcohol group supports integration into multi-step labeling schemes used in research tool generation.

4. Diagnostic Reagent And Assay Tags

Azido-PEG7-alcohol is well suited for preparing assay-compatible conjugation reagents and tagged components used in diagnostic research workflows. The reagent’s PEG spacer and azide functionality support consistent coupling to alkyne-bearing detection elements, enabling modular assembly of multicomponent assay systems such as labeled binding reagents, polymer-tagged readouts, and platform-ready conjugates. Its alcohol handle can be used to introduce additional chemical functionality for immobilization or for tailoring reagent behavior in assay buffers and conjugation workflows.