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Azido-PEG6-PFP ester | CAS 1818294-47-1
| Catalog Number | R14-0295 |
| Category | Azides |
| Molecular Formula | C₂₁H₂₈F₅N₃O₈ |
| Molecular Weight | 545.45 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG6-PFP ester is a polyethylene glycol (PEG)-based PROTAC linker. Azido-PEG6-PFP ester can be used in the synthesis of a series of PROTACs.
Chemical Information
Product Specification
Application
Computed Properties
| Synonyms | 2,3,4,5,6-PENTAFLUOROPHENYL 1-AZIDO-3,6,9,12,15,18-HEXAOXAHENICOSAN-21-OATE; (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Purity | 98% |
| IUPAC Name | (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])C(=O)OC1=C(C(=C(C(=C1F)F)F)F)F |
| InChI | InChI=1S/C21H28F5N3O8/c22-16-17(23)19(25)21(20(26)18(16)24)37-15(30)1-3-31-5-7-33-9-11-35-13-14-36-12-10-34-8-6-32-4-2-28-29-27/h1-14H2 |
| InChIKey | YVHKCEARDWOLPA-UHFFFAOYSA-N |
| Solubility | DCM |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Azido-PEG6-PFP ester, a versatile chemical reagent widely employed in bioconjugation and molecular labeling, finds applications across diverse fields. Here are four key applications of Azido-PEG6-PFP ester:
Protein Labeling: Positioned as a cornerstone in the labeling and modification of proteins, Azido-PEG6-PFP ester serves as a pivotal tool in exploring protein-protein interactions within various biological systems. By engaging with primary amines on proteins, it facilitates the incorporation of azide groups, paving the way for subsequent conjugation with other molecules through click chemistry. This intricate method is indispensable for tracking and dissecting protein interactions at a molecular level, illuminating the complexities of biological processes with intricate precision.
Drug Delivery Systems: Within the intricate domain of drug delivery systems, Azido-PEG6-PFP ester emerges as a critical modifier for drug molecules or carrier nanoparticles, aiming to elevate targeting precision and therapeutic efficacy. The strategic inclusion of azide groups allows for the attachment of targeting ligands or functional moieties via bio-orthogonal reactions, enhancing the specificity of drug delivery to desired cellular targets. This sophisticated strategy revolutionizes the targeted drug delivery landscape, offering bespoke solutions for optimal therapeutic outcomes with unparalleled accuracy.
Imaging and Diagnostics: In the dynamic realm of molecular imaging and diagnostics, Azido-PEG6-PFP ester assumes a pivotal role in enhancing the visualization of cellular processes and disease markers. Through the conjugation of this reagent with imaging probes, researchers can achieve selective labeling of biomolecules, paving the way for sophisticated diagnostic tools with heightened precision. This application stands at the vanguard of medical imaging advancements, facilitating a deeper comprehension of disease progression and cellular dynamics through meticulous molecular labeling techniques.
Surface Functionalization: Extending its utility to the domain of surface functionalization, Azido-PEG6-PFP ester offers a versatile approach to tailor surfaces in microarrays, biosensors, and biomaterials. By affixing azide groups to surface molecules, researchers can craft reactive surfaces with precision, primed for subsequent immobilization of biomolecules. This intricate technique underpins the development of advanced biointerface materials, enabling the design and fabrication of intricate surfaces for a multitude of applications in biotechnology and medical research.
| XLogP3 | 2.1 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 15 |
| Rotatable Bond Count | 23 |
| Exact Mass | 545.17965567 g/mol |
| Monoisotopic Mass | 545.17965567 g/mol |
| Topological Polar Surface Area | 96Ų |
| Heavy Atom Count | 37 |
| Formal Charge | 0 |
| Complexity | 637 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
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