Azido-PEG6-Br | CAS 2062663-64-1

Name: Azido-PEG6-Br
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0180
Category	Azides
Molecular Formula	C14H28BrN3O6
Molecular Weight	414.30

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Product Introduction

Azido-PEG6-Br is a bifunctional PEG linker with a bromide (Br) group and an azide (N3) group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The bromide (Br) is a good leaving group for nucleophilic substitution reactions.

Chemical Information
Product Specification
Application

Synonyms	Bromo-PEG6-azide;Bromo-PEG6-Azide; Br-PEG6-N3; N3-PEG6-CH2CH2Br; 1-Azido-20-bromo-3,6,9,12,15,18-hexaoxaicosane; 3,6,9,12,15,18-Hexaoxaeicosane, 1-azido-20-bromo-
Purity	≥95%
IUPAC Name	1-azido-2-[2-[2-[2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethane
Canonical SMILES	C(COCCOCCOCCOCCOCCOCCBr)N=[N+]=[N-]
InChI	InChI=1S/C14H28BrN3O6/c15-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-17-18-16/h1-14H2
InChIKey	LTHQYKLNICEFNE-UHFFFAOYSA-N
Appearance	Pale Yellow or Colorless Oily Matter

Storage

Store at 2-8°C

Azido-PEG6-Br is a bifunctional reagent used for bioconjugation, labeling, and surface modification processes in biosciences. Here are some key applications of Azido-PEG6-Br.

Click Chemistry: Azido-PEG6-Br is employed in click chemistry reactions to create stable, covalent bonds between molecules. The azide group reacts with alkynes via a copper-catalyzed azide-alkyne cycloaddition, allowing for efficient and specific conjugation of biomolecules. This technique is widely used for the synthesis of complex bioconjugates and the modification of surfaces in nanotechnology and drug delivery systems.

Protein Labeling: Azido-PEG6-Br facilitates the labeling of proteins for various analytical and preparative purposes. By conjugating this reagent to specific amino acid residues, researchers can attach fluorescent dyes, biotin, or other tags to proteins. This aids in studying protein interactions, tracking protein localization, and purifying tagged proteins through affinity methods.

Surface Modification: Azido-PEG6-Br can be applied in the functionalization of various surfaces, including nanoparticles, microarrays, and biosensors. The polyethylene glycol (PEG) spacer enhances solubility and reduces nonspecific binding, while the azide group enables further functionalization through click chemistry. This application is essential for designing advanced materials with tailored surface properties for biomedical and diagnostic applications.

Drug Delivery Systems: Azido-PEG6-Br is useful in the creation of targeted drug delivery systems. By attaching targeting moieties, such as antibodies or ligands, through click chemistry, therapeutic agents can be directed to specific cells or tissues. This approach helps in enhancing the efficacy and specificity of treatments, thereby reducing side effects and improving patient outcomes.