Azido-PEG6-amine | CAS 957486-82-7

Name: Azido-PEG6-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0265
Category	Azides
Molecular Formula	C14H30N4O6
Molecular Weight	350.41

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Product Introduction

Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

Chemical Information
Product Specification
Computed Properties
Patents

Synonyms	O-(2-Aminoethyl)-O'-(2-azidoethyl)pentaethylene Glycol; N3-PEG6-CH2CH2NH2; 20-azido-3,6,9,12,15,18-hexaoxaicosan-1-amine; N3-PEG6-NH2
Purity	≥95%
IUPAC Name	2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES	C(COCCOCCOCCOCCOCCOCCN=[N+]=[N-])N
InChI	InChI=1S/C14H30N4O6/c15-1-3-19-5-7-21-9-11-23-13-14-24-12-10-22-8-6-20-4-2-17-18-16/h1-15H2
InChIKey	VCQSTKKJKNUQBI-UHFFFAOYSA-N
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Pale Yellow or Colorless Oily Matter
LogP	0.50806

Storage	Store at -20°C, keep in dry and avoid sunlight
Signal	Warning
GHSHazardStatements	H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

XLogP3	-0.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	20
Exact Mass	350.21653469 g/mol
Monoisotopic Mass	350.21653469 g/mol
Topological Polar Surface Area	95.8Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	292
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Publication Number	Title	Priority Date
WO-2022219409-A2	Compositions containing nucleic acid nanoparticles and processes related to alteration of their physicochemical characteristics	2021-04-15
WO-2022162549-A2	Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses	2021-01-27
US-2022143231-A1	Macrocyclic compounds and methods of use thereof	2020-11-10
WO-2022101771-A1	Macrocyclic compounds and methods of use thereof	2020-11-10
US-2022072141-A1	Protein-drug conjugates comprising camptothecin analogs and methods of use thereof	2020-07-13