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Azido-PEG5-alcohol | 86770-68-5
| Catalog Number | R14-0217 |
| Category | Azides |
| Molecular Formula | C10H21N3O5 |
| Molecular Weight | 263.29 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| R14-0217 | -- | $-- |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- Chemical Information
- Product Specification
| Synonyms | 14-Azido-3,6,9,12-tetraoxatetradecanol; 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol |
| Purity | >98.0% |
| Shelf Life | ≥ 2 years |
| IUPAC Name | 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanol |
| Canonical SMILES | C(COCCOCCOCCOCCO)N=[N+]=[N-] |
| InChI | InChI=1S/C10H21N3O5/c11-13-12-1-3-15-5-7-17-9-10-18-8-6-16-4-2-14/h14H,1-10H2 |
| InChI Key | JTGGTGKXQQGEHB-UHFFFAOYSA-N |
| Solubility | 10 mm in DMSO |
| Appearance | Colorless to light orange to yellow clear liquid |
| LogP | -1.59 |
| Storage | Store at -20 °C, keep in dry and avoid sunlight. |
Computed Properties | |
|---|---|
| XLogP3 | -0.1 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 14 |
| Exact Mass | 263.14812078 g/mol |
| Monoisotopic Mass | 263.14812078 g/mol |
| Topological Polar Surface Area | 71.5Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 212 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| US-2021322331-A1 | Nanocapsules for the delivery of cell modulating agents | 2018-12-23 |
| CA-3118142-A1 | Therapeutic methods | 2018-11-02 |
| EP-3873530-A1 | Therapeutic methods | 2018-11-02 |
| US-2022031847-A1 | Therapeutic methods | 2018-11-02 |
| US-2022356185-A1 | Mertk degraders and uses thereof | 2018-07-06 |
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