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Azido-PEG4-PFP ester | CAS 1353012-00-6
| Catalog Number | R14-0297 |
| Category | Azides |
| Molecular Formula | C17H20F5N3O6 |
| Molecular Weight | 457.4 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
Azido-PEG4-PFP ester is a versatile chemical compound widely used in the biomedicine field. This ester derivative is utilized for the modification and functionalization of biomolecules, such as peptides and proteins. Its azido group allows for further conjugation or attachment to various drugs, biomaterials, or surfaces. This enables targeted drug delivery, protein labeling, and immunoassays for disease diagnostics and therapeutics.
Chemical Information
Product Specification
Application
Computed Properties
Patents
| Synonyms | perfluorophenyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate |
| Purity | ≥98% |
| IUPAC Name | (2,3,4,5,6-pentafluorophenyl) 3-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]propanoate |
| Canonical SMILES | C(COCCOCCOCCOCCN=[N+]=[N-])C(=O)OC1=C(C(=C(C(=C1F)F)F)F)F |
| InChI | InChI=1S/C17H20F5N3O6/c18-12-13(19)15(21)17(16(22)14(12)20)31-11(26)1-3-27-5-7-29-9-10-30-8-6-28-4-2-24-25-23/h1-10H2 |
| InChIKey | QSIFGTAWLLFXPY-UHFFFAOYSA-N |
| Solubility | DMSO, DCM, DMF |
| Appearance | Soild powder |
| Storage | -20 °C |
Azido-PEG4-PFP ester, a versatile chemical reagent, finds application in diverse bioconjugation and labeling contexts. Here are four key applications of Azido-PEG4-PFP ester:
Biomedical Research: Employing this reagent enables site-specific modification of biomolecules like proteins and peptides using azide-alkyne click chemistry. Azido-PEG4-PFP ester furnishes a reactive azide group and a pentafluorophenyl ester for selective conjugation. This technique is pivotal for investigating protein-protein interactions and crafting targeted therapeutics with precision.
Diagnostics: In the realm of diagnostics, Azido-PEG4-PFP ester plays a crucial role in formulating diagnostic assays and imaging tools. Its capability to attach fluorescent dyes or radiolabels to antibodies or targeting molecules enhances the sensitivity and specificity of diagnostic tests, aiding in early disease detection.
Drug Delivery: Within drug delivery research, Azido-PEG4-PFP ester serves as a valuable tool for modifying drug carriers such as nanoparticles and liposomes. Through click chemistry, these carriers can be adorned with targeting ligands or therapeutic agents, enabling precise drug delivery to diseased cells. This targeted approach not only enhances efficacy but also minimizes the side effects of chemotherapeutic agents.
Material Science: Extending its utility to material science, Azido-PEG4-PFP ester facilitates the functionalization of diverse surfaces and materials. By introducing bioactive compounds onto surfaces like sensors, biomaterials, and microfluidic devices, it enhances biocompatibility and functionality, broadening their scope in applications like biosensing and tissue engineering.
| XLogP3 | 2.4 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 17 |
| Exact Mass | 457.12722618 g/mol |
| Monoisotopic Mass | 457.12722618 g/mol |
| Topological Polar Surface Area | 77.6Ų |
| Heavy Atom Count | 31 |
| Formal Charge | 0 |
| Complexity | 544 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022150726-A1 | Hypoimmunogenic biotherapeutics | 2021-01-11 |
| WO-2022150721-A1 | Bifunctional folate receptor binding compounds | 2021-01-08 |
| EP-4087584-A2 | Cell surface receptor binding compounds and conjugates | 2020-01-10 |
| JP-2018127496-A | XTEN conjugate composition and method for producing the same | 2012-02-27 |
| JP-2018130123-A | XTEN conjugate composition and method for producing the same | 2012-02-27 |
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