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Azido-PEG4-amine | CAS 951671-92-4
| Catalog Number | R14-0267 |
| Category | Azides |
| Molecular Formula | C10H22N4O4 |
| Molecular Weight | 262.31 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
N3-PEG4-C2-NH2 is a polyethylene glycol (PEG)-based PROTAC linker. N3-PEG4-C2-NH2 can be used in the synthesis of a series of PROTACs. N3-PEG4-C2-NH2 is a PEG derivative containing an amino group with an azide group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | 14-Azido-3,6,9,12-tetraoxatetradecan-1-amine; O-(2-Aminoethyl)-O'-(2-azidoethyl)triethylene Glycol; N3-PEG4-C2-NH2; N3-PEG4-CH2CH2NH2; 14-Amino-3,6,9,12-tetraoxatetradecanyl Azide; 1-Amino-14-azido-3,6,9,12-tetraoxatetradecane |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanamine |
| Canonical SMILES | C(COCCOCCOCCOCCN=[N+]=[N-])N |
| InChI | InChI=1S/C10H22N4O4/c11-1-3-15-5-7-17-9-10-18-8-6-16-4-2-13-14-12/h1-11H2 |
| InChIKey | ZMBGKXBIVYXREN-UHFFFAOYSA-N |
| Solubility | Soluble in DCM, DMF, DMSO, Water |
| Density | 1.10 g/mL |
| Appearance | Colorless to Light Yellow to Light Orange Liquid |
| LogP | 0.47486 |
| Storage | Store at 2-8°C |
| Signal | Danger |
| GHSHazardStatements | H314 (50%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
| Precautionary Statement Codes | P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501 |
| XLogP3 | -0.4 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 14 |
| Exact Mass | 262.16410520 g/mol |
| Monoisotopic Mass | 262.16410520 g/mol |
| Topological Polar Surface Area | 77.3Ų |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
| Complexity | 212 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022263944-A1 | Azido-containing monomers, polymers, and articles | 2021-06-16 |
| WO-2022211075-A1 | Method for manufacturing antibody-drug conjugate and enzyme used for same | 2021-03-31 |
| WO-2022162549-A2 | Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses | 2021-01-27 |
| CN-112480081-B | Difunctional molecular compound for inducing SHP2 protein degradation based on Cereblan ligand | 2020-12-07 |
| US-2022143231-A1 | Macrocyclic compounds and methods of use thereof | 2020-11-10 |
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