Azido-PEG4-amine | 951671-92-4

Name: Azido-PEG4-amine
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog Number	R14-0267
Category	Azides
Molecular Formula	C10H22N4O4
Molecular Weight	262.31

Catalog Number	Size	Price	Quantity
R14-0267	--	$--

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Product Introduction

N3-PEG4-C2-NH2 is a polyethylene glycol (PEG)-based PROTAC linker. N3-PEG4-C2-NH2 can be used in the synthesis of a series of PROTACs. N3-PEG4-C2-NH2 is a PEG derivative containing an amino group with an azide group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage.

Chemical Information
Product Specification

Synonyms	14-Azido-3,6,9,12-tetraoxatetradecan-1-amine; O-(2-Aminoethyl)-O'-(2-azidoethyl)triethylene Glycol; N3-PEG4-C2-NH2; N3-PEG4-CH2CH2NH2; 14-Amino-3,6,9,12-tetraoxatetradecanyl Azide; 1-Amino-14-azido-3,6,9,12-tetraoxatetradecane
Purity	≥95%
IUPAC Name	2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethanamine
Canonical SMILES	C(COCCOCCOCCOCCN=[N+]=[N-])N
InChI	InChI=1S/C10H22N4O4/c11-1-3-15-5-7-17-9-10-18-8-6-16-4-2-13-14-12/h1-11H2
InChI Key	ZMBGKXBIVYXREN-UHFFFAOYSA-N
Solubility	Soluble in DCM, DMF, DMSO, Water
Density	1.10 g/mL
Appearance	Colorless to Light Yellow to Light Orange Liquid
LogP	0.47486

Storage	Store at 2-8°C
Signal	Danger
GHS Hazard Statements	H314 (50%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] H315 (50%): Causes skin irritation [Warning Skin corrosion/irritation] H318 (50%): Causes serious eye damage [Danger Serious eye damage/eye irritation] H319 (50%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (50%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]
Precautionary Statement Codes	P260, P261, P264, P264+P265, P271, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P319, P321, P332+P317, P337+P317, P362+P364, P363, P403+P233, P405, and P501

Computed Properties
XLogP3	-0.4
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	14
Exact Mass	262.16410520 g/mol
Monoisotopic Mass	262.16410520 g/mol
Topological Polar Surface Area	77.3Å²
Heavy Atom Count	18
Formal Charge	0
Complexity	212
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Patents

Publication Number	Title	Priority Date
WO-2022263944-A1	Azido-containing monomers, polymers, and articles	2021-06-16
WO-2022211075-A1	Method for manufacturing antibody-drug conjugate and enzyme used for same	2021-03-31
WO-2022162549-A2	Immunoconjugates comprising kallikrein related peptidase 2 antigen binding domains and their uses	2021-01-27
CN-112480081-B	Difunctional molecular compound for inducing SHP2 protein degradation based on Cereblan ligand	2020-12-07
US-2022143231-A1	Macrocyclic compounds and methods of use thereof	2020-11-10