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Azido-PEG3-t-butyl ester | CAS 252881-73-5
| Catalog Number | R14-0243 |
| Category | Azides |
| Molecular Formula | C13H25N3O5 |
| Molecular Weight | 303.35 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | N3-PEG3-CH2CH2COOtBu;N3-PEG3-tBu; N3-PEG3-CH2CH2-Boc; 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester; tert-Butyl 12-azido-4,7,10-trioxadocecanoate; 12-Azido-4,7,10-trioxadodecanoic acid tert-butyl ester; 2-Methyl-2-propanyl 3-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}propanoate; Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-, 1,1-dimethylethyl ester |
| Purity | ≥95% |
| Shelf Life | 0-4°C for short term (days to weeks), or -20°C for long term (months). |
| IUPAC Name | tert-butyl 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]propanoate |
| Canonical SMILES | CC(C)(C)OC(=O)CCOCCOCCOCCN=[N+]=[N-] |
| InChI | InChI=1S/C13H25N3O5/c1-13(2,3)21-12(17)4-6-18-8-10-20-11-9-19-7-5-15-16-14/h4-11H2,1-3H3 |
| InChIKey | QUSLQIYNPWASRR-UHFFFAOYSA-N |
| Solubility | Soluble in DMSO (10 mm) |
| Appearance | Pale Yellow or Colorless Oily Matter |
| LogP | 1.53106 |
| Storage | Store at -20°C, keep in dry and avoid sunlight |
| XLogP3 | 1.5 |
| Hydrogen Bond Donor Count | 0 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 14 |
| Exact Mass | 303.17942091 g/mol |
| Monoisotopic Mass | 303.17942091 g/mol |
| Topological Polar Surface Area | 68.4Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 324 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022078524-A2 | Specific conjugation of an antibody | 2021-11-03 |
| WO-2022078524-A4 | Specific conjugation of an antibody | 2021-11-03 |
| JP-2021006531-A | Cross-linked conjugate for conjugation of cell-binding molecules | 2020-09-01 |
| JP-7149610-B2 | Specific conjugates of cell binding molecules | 2019-11-22 |
| US-2022249594-A1 | A formulation of a conjugate of a tubulysin analog to a cell-binding molecule | 2019-06-24 |
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