Azido-PEG3-acetic acid | CAS 172531-37-2

Catalog Number	R14-0274
Category	Azides
Molecular Formula	C8H15N3O5
Molecular Weight	233.22

Catalog Number	Size	Price	Quantity
R14-0274	5 g	$899

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Product Introduction

N3-PEG3-CH2COOH is a PROTAC linker, which refers to the alkyl/ether composition. N3-PEG3-CH2COOH can be used in the synthesis of a series of PROTACs. N3-PEG3-CH2COOH is a PEG derivative containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.

Chemical Information
Product Specification

Related CAS	2713329-79-2 (CHA salt) 2260791-81-7 (monocesium salt)
Synonyms	Azido-PEG3-CH2CO2H; 11-Azido-3,6,9-trioxaundecanoic Acid; N3-PEG3-CH2COOH; {2-[2-(2-Azidoethoxy)ethoxy]ethoxy}acetic acid; Acetic acid, 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-; Azido-PEG3-CH2COOH; N3-AEEEA; Azido-PEG3-propionic acid
Purity	95%
IUPAC Name	2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetic acid
Canonical SMILES	C(COCCOCCOCC(=O)O)N=[N+]=[N-]
InChI	InChI=1S/C8H15N3O5/c9-11-10-1-2-14-3-4-15-5-6-16-7-8(12)13/h1-7H2,(H,12,13)
InChIKey	GIXBCECBLAEYKA-UHFFFAOYSA-N
Solubility	Soluble in DCM, DMF, DMSO, Water
Appearance	Light Yellow to Brown Clear Liquid
LogP	-0.11614

Storage	Store at 2-8 °C
Signal	Warning
Precautionary Statement Codes	P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364