Azido-PEG2-NHS ester | 1312309-64-0

Azido-PEG2-NHS ester, a versatile chemical reagent for bioconjugation and molecular biology, finds diverse applications in various domains. Here are the key applications of Azido-PEG2-NHS ester:

Protein Labeling: Utilizing NHS ester chemistry, Azido-PEG2-NHS ester facilitates the attachment of azide groups to proteins by reacting with primary amines on lysine residues. This sets the stage for subsequent “click” chemistry reactions, enabling the conjugation of the azide to various alkyne-tagged probes. This method proves invaluable for tracking and studying proteins within intricate biological systems, unraveling the intricacies of protein dynamics.

Drug Delivery Systems: In the realm of drug delivery systems, Azido-PEG2-NHS ester emerges as a crucial player, capable of modifying nanoparticles or carrier molecules. By leveraging click chemistry to attach targeting ligands or therapeutic agents, researchers craft highly specific drug delivery vehicles. This innovative approach not only boosts the efficacy of therapeutic agents but also mitigates their toxicity, heralding a new era in precision medicine.

Bioorthogonal Chemistry: At the forefront of bioorthogonal chemistry, Azido-PEG2-NHS ester plays a pivotal role, empowering the selective labeling of biomolecules without disrupting natural biological processes. Through bio-compatible reactions between azides and alkynes in living cells, this reagent enables precise labeling for live-cell imaging and real-time exploration of dynamic biological interactions. This strategy revolutionizes the field of molecular biology, offering unprecedented insights into cellular activities.

Surface Modification: Azido-PEG2-NHS ester serves as a key tool in functionalizing surfaces of biosensors, microarrays, and medical devices with azide groups. These tailored surfaces pave the way for conjugating diverse biomolecules using click chemistry, expanding applications in diagnostics, biomarker detection, and tissue engineering. This enhancement bolsters the specificity and functionality of biosensor platforms, opening new avenues for cutting-edge research and development.