Azido-PEG11-alcohol | CAS 2252392-53-1

Azido-PEG11-alcohol is a PEG-based azide building block designed for copper-free or copper-mediated click chemistry workflows, offering a flexible, hydrophilic spacer that improves solubility and reduces nonspecific interactions. As an azide-functional reagent, it serves as a versatile handle for strain-promoted azide–alkyne cycloaddition (SPAAC) or CuAAC conjugation strategies, enabling downstream attachment of biomolecules, targeting ligands, or imaging moieties. The terminal alcohol further supports formulation flexibility and surface or polymer compatibility in materials and assay reagent development.

1. Biomolecule Conjugation

Azido-PEG11-alcohol is frequently used as a PEG linker component to introduce an azide functional group onto proteins, peptides, antibodies, and other biomolecular scaffolds for subsequent click-based attachment of reporters or affinity tags. Researchers value the long, flexible PEG spacer to help maintain accessibility of the azide during labeling and to mitigate steric hindrance that can reduce conjugation efficiency in crowded bioconjugation settings. The reagent’s hydrophilic PEG chain also supports aqueous handling for labeling workflows used in chemical biology and biomaterials laboratories.

2. Fluorescent Probe Labeling

Azido-PEG11-alcohol supports the preparation of fluorescent detection reagents by providing an azide handle that can be clicked to alkyne-bearing dyes, fluorogenic reporters, or imaging-compatible chromophores. The PEG11 spacer helps tune probe behavior in solution by improving dispersibility and reducing aggregation tendencies that can complicate optical readouts. This makes the reagent a common choice in assay development and molecular imaging research where stable, well-behaved conjugates are needed for consistent labeling and downstream characterization.

3. Surface And Polymer Functionalization

Azido-PEG11-alcohol is widely applied in materials science to functionalize surfaces, nanoparticles, and polymer platforms with azide groups for later click coupling to patterned ligands, capture molecules, or reactive handles. The combination of a long PEG tether and terminal alcohol facilitates compatibility with coating, blending, and surface modification workflows that require robust integration into hydrophilic environments. In many lab and industrial settings, this azide-functional PEG alcohol serves as a modular intermediate for assembling multicomponent materials via stepwise click conjugation.

4. Diagnostic Reagent Development

Azido-PEG11-alcohol is used to build azide-bearing components for diagnostic and analytical reagent platforms that rely on modular conjugation chemistry. By installing an azide handle with a PEG11 spacer, developers can couple standardized recognition elements, signal-generating tags, or assay-compatible capture chemistries through click reactions under conditions suited to sensitive reagent formats. The reagent’s aqueous compatibility and spacer-driven reduction of nonspecific interactions make it practical for constructing multivalent assay reagents used in research-grade detection workflows.