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AkaLumine | CAS 1176235-08-7
| Catalog Number | A18-0107 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C16H18N2O2S |
| Molecular Weight | 302.39 |
* Please be kindly noted products are not for therapeutic use. We do not sell to patients.
Product Introduction
AkaLumine is a luciferin analog. The bioluminescence produced by AkaLumine in reactions with native firefly luciferase is in the near-infrared wavelength ranges (λmax=677 nm), and yields significantly increased target-detection sensitivity from deep tissues with maximal signals attained at very low concentrations.
Chemical Information
Product Specification
Computed Properties
Patents
| Synonyms | 4,5-dihydrothiazole-4-carboxylic acid; 2-[(1E,3E)-4-(4-Dimethylaminophenyl)buta-1,3-dienyl]-; 2-[(1E,3E)-4-(4-Dimethylaminophenyl)buta-1,3-dienyl]- 4,5-dihydrothiazole-4-carboxylic acid; 2-[(1E,3E)-4-[4-(dimethylamino)phenyl]buta-1,3-dien-1-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid |
| IUPAC Name | 2-[(1E,3E)-4-[4-(dimethylamino)phenyl]buta-1,3-dienyl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid |
| Canonical SMILES | CN(C)C1=CC=C(C=C1)C=CC=CC2=NC(CS2)C(=O)O |
| InChI | InChI=1S/C16H18N2O2S/c1-18(2)13-9-7-12(8-10-13)5-3-4-6-15-17-14(11-21-15)16(19)20/h3-10,14H,11H2,1-2H3,(H,19,20)/b5-3+,6-4+ |
| InChIKey | ULTVSKXCSMDCHR-GGWOSOGESA-N |
| Solubility | Soluble in DMSO. |
| Density | 1.2±0.1 g/cm3 |
| Appearance | Solid Powder |
| Boiling Point | 541.4±60.0 °C at 760 mmHg |
| Emission | 677 |
| Storage | Store at -20°C |
| XLogP3 | 3 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 5 |
| Exact Mass | 302.10889899 g/mol |
| Monoisotopic Mass | 302.10889899 g/mol |
| Topological Polar Surface Area | 78.2Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 449 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 1 |
| Defined Bond Stereocenter Count | 2 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2022050233-A1 | Light-emitting system and cytochrome p450 quantification method | 2020-09-03 |
| US-2019227077-A1 | Assays for Detecting Antibodies Capable of Mediating Antibody-Dependent Cell-Mediated Cytotoxicity | 2018-01-25 |
| US-11402380-B2 | Assays for detecting antibodies capable of mediating antibody-dependent cell-mediated cytotoxicity | 2018-01-25 |
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