Mca-DEVDAPK(Dnp)-OH | CAS 189696-20-6

Catalog Number	A18-0042
Category	Fluorescent Enzyme Substrates
Molecular Formula	C50H62N10O22
Molecular Weight	1155.1

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Product Introduction

Mca-DEVDAPK(Dnp)-OH is a synthetic fluorogenic peptide probe that features a 7-methoxycoumarin (Mca) fluorophore and a dinitrophenyl (Dnp) quencher. This compound is designed to participate in fluorescence resonance energy transfer (FRET) assays, where cleavage by specific proteases releases the fluorophore, resulting in a measurable increase in fluorescence. It is commonly used in biochemical research to study enzyme kinetics and caspase activity, providing insights into apoptotic pathways and proteolytic processes.

Chemical Information
Product Specification

Chemical Information

Synonyms	Caspase-3 Fluorogenic Substrate III; CPP32 Fluorogenic Substrate III; 7-Methoxycoumarin-4-acetyl-DEVDAPK(Dnp)-OH; N-[(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)acetyl]-L-α-aspartyl-L-α-glutamyl-L-valyl-L-α-aspartyl-L-alanyl-L-prolyl-N6-(2,4-dinitrophenyl)-L-lysine
Purity	≥95%
SMILES	CC(C)C(C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)N1CCCC1C(=O)NC(CCCCNC2=C(C=C(C=C2)[N+](=O)[O-])[N+](=O)[O-])C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)CC3=CC(=O)OC4=C3C=CC(=C4)OC
InChI	InChI=1S/C50H62N10O22/c1-24(2)43(57-44(69)31(14-15-39(62)63)54-46(71)33(22-40(64)65)53-38(61)18-26-19-42(68)82-37-21-28(81-4)11-12-29(26)37)48(73)56-34(23-41(66)67)45(70)52-25(3)49(74)58-17-7-9-35(58)47(72)55-32(50(75)76)8-5-6-16-51-30-13-10-27(59(77)78)20-36(30)60(79)80/h10-13,19-21,24-25,31-35,43,51H,5-9,14-18,22-23H2,1-4H3,(H,52,70)(H,53,61)(H,54,71)(H,55,72)(H,56,73)(H,57,69)(H,62,63)(H,64,65)(H,66,67)(H,75,76)/t25-,31-,32-,33-,34-,35-,43-/m0/s1
InChIKey	YOUVSUDOGAVRQX-AEAFXXELSA-N