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H-Gly-Gly-AMC | 208645-74-3
| Catelog Number | A18-0051 |
| Category | Fluorescent Enzyme Substrates |
| Molecular Formula | C14H15N3O4 |
| Molecular Weight | 289.3 |
| Catalog Number | Size | Price | Quantity |
|---|---|---|---|
| A18-0051 | -- | $-- |
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Product Introduction
Gly-Gly-AMC is a fluorogenic substrate for detecting the activity of bacterial proteases from P. aeruginosa and S. aureus. AMC (7-amino-4-methylcoumarin) is released and its fluorescence can be used to quantify the protease activity.
Chemical Information |
|
|---|---|
| Synonyms | Glycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-glycinamide |
| Purity | ≥98% |
| IUPAC Name | 2-amino-N-[2-[(4-methyl-2-oxochromen-7-yl)amino]-2-oxoethyl]acetamide |
| Canonical SMILES | CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)CNC(=O)CN |
| InChI | InChI=1S/C14H15N3O4/c1-8-4-14(20)21-11-5-9(2-3-10(8)11)17-13(19)7-16-12(18)6-15/h2-5H,6-7,15H2,1H3,(H,16,18)(H,17,19) |
| InChI Key | LPLILQIZVFKNJC-UHFFFAOYSA-N |
| Appearance | Solid Powder |
Product Specification |
|
|---|---|
| Excitation | 340-360 nm |
| Emission | 440-460 nm |
| Storage | Store at -20°C |
Computed Properties | |
|---|---|
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 4 |
| Exact Mass | 289.10625597 g/mol |
| Monoisotopic Mass | 289.10625597 g/mol |
| Topological Polar Surface Area | 111Ų |
| Heavy Atom Count | 21 |
| Formal Charge | 0 |
| Complexity | 475 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| Covalently-Bonded Unit Count | 1 |
| Compound Is Canonicalized | Yes |
Patents
| Publication Number | Title | Priority Date |
|---|---|---|
| WO-2009009773-A1 | Use of otubain enzyme to cleave lysine-48-linked polyubiquitin | 2007-07-11 |
| US-6017768-A | Combinatorial dihydrobenzopyran library | 1994-05-06 |
| US-6790965-B1 | Combinatorial dihydrobenzopyran library | 1994-05-06 |
Applications of Fluorescent Probes & Dyes
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